#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

RT @amazonwatch
A 🧵on some underreported facts👇🏾for #JournalistTwitter on mining in the Amazon, especially those covering the world’s largest mining convention happening in Toronto, Canada next week. #PDAC

📸Gold mining area, in Porto Velho, Brazil ©Victor Moriyama/Amazon in Flames Alliance

"In this work, we explored possibility of using drug-sensitivity data together with basal gene expression data on pancreatic cell lines to predict the combinatorial options available for HDACi and developed bioinformatics screening protocol for predictions of synergistic drug combinations in PDAC. "

#Preprint #PDAC #HDAC

https://www.biorxiv.org/content/10.1101/2022.10.10.511584v3

Important ESPAC-5 study on neoadjuvant treatment of #pancreatic #cancer #pdac .

Again just like the A021501 trial (10.1001/jamaoncol.2022.2319) showing that radiotherapy is not a good idea for patients in the neoadjuvant setting. Pancreatic cancer is a systemic disease from early on and must be treated as such.

https://doi.org/10.1016/S2468-1253(22)00348-X

'Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest major cancers, contrasting a relatively low incidence rate1. The primary reasons for this are related to the difficulty with early detection and a lack of effective therapeutic options. A principal barrier to treatment of pancreatic cancer is the densely fibrotic tumor microenvironment, the high interstitial pressure of which acts to collapse blood vessels and impair the delivery of chemotherapy. This lack of functional vasculature leads to deregulated nutrient availability within the tumor, causing cancer cells to develop numerous metabolic adaptations to allow for proliferation under hypoxic and austere conditions'

#PDAC #CancerMetabolism

https://www.nature.com/articles/s43018-022-00463-1

Sometimes fate throws a #PublicHealth issue your way. Today is World #PancreaticCancer Day & as I contemplate the extraordinary care we received at #ColumbiaPresbyterian & #MSKCC, I’m reminded of those who haven’t access to such care. We were lucky…….but you shouldn’t have to be. #PancreasCancer #PDAC

Sometimes fate throws a #PublicHealth issue your way. Today is World #PancreaticCancer Day & as I contemplate the extraordinary care we received at #ColumbiaPresbyterian & #MSKCC, I’m reminded of those who haven’t access to such care. We were lucky…….but you shouldn’t have to be. #PDAC #PancreasCancer

Today is World #PancreaticCancer Day. Along with remembering those who lost their lives to #PancreasCancer since #WPCD 2021, I’m remembering Jay and feeling hopeful that science is on the precipice of a deeper understanding of the complexities of #PDAC.

Today is World #PancreaticCancer Day. Along with remembering those who lost their lives to #PancreasCancer since #WPCD 2021, I’m remembering Jay and feeling hopeful that science is on the precipice of a deeper understanding of the complexities of #PDAC.