This is intriguing: phage therapy induces bacterial resistance but also reduced virulence.

So clinical benefit post-phage could also stem from bacterial attenuation rather than just eradication.

Question is how sustainable this effect may be.
#Phages #bacteria #microbiology #IDMastodon #medicine #MedMastodon #AMR #antibiotics #bacteriophage
https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00405-6/fulltext?dgcid=raven_jbs_aip_email

I only just hear about #mycobacteriophages as potential therapeutics and already learn about resistance mechanisms.

Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates

https://www.nature.com/articles/s41564-023-01451-6

#AMR #phages #IDMastodon #InfectiousDiseases #Mycobacterium

Meet #Microbiology2023 speaker Rotem Sorek. At the Weizmann Institute of Science, he investigates the interactions between #bacteria and the viruses that infect them. He studies how these #phages attack bacteria, and how bacteria defend themselves against such attacks. https://microbiology2023.de

The Interacademy Conference is organized by the German National Academy of Sciences Leopoldina, the Académie des sciences, the Royal Society, and the Royal Swedish Academy of Sciences.

'While recent events have provided a painful reminder of the very bad viruses that prey on us, Tom Ireland’s “The Good Virus” is a colorful redemption story for the oft-neglected yet incredibly abundant phage, and its potential for quelling the existential threat of antibiotic resistance, which scientists estimate might cause up to 10 million deaths per year by 2050.' #books #viruses #phages #health
https://www.nytimes.com/2023/08/15/books/review/the-good-virus-tom-ireland-the-master-builder-alfonso-martinez-arias.html

#Microbiology #IDMastodon #phages are viruses that infect bacteria and hijack the cell machinery to replicate. Phages exhibit two main types of lifestyle.
The lytic cycle involves the expression of phage nucleic acids, leading to the production of both the phage genome and proteins that will be assembled into new virions. At the end of a lytic cycle, the host cell is lysed, and the progeny phages are released.

ASM is now taking session proposals for the 2024 Microbe meeting in Atlanta, Georgia

#ASM #Microbiology #MicrobialEvolution #MicrobialEcology #Phage #Phages #Bacteria

https://asm.org/Events/ASM-Microbe/Session-Proposals?_zs=eKArl&_zl=bePd2

The first #Canadian study using #phages to treat #superbug infections is underway with scientists reporting a preliminary but encouraging early success case.

"You are considered clinically and biologically cured," said Victoria Marshall as she read a text message from her doctor on the latest test results.
It brought her to tears.

"Well, I can have my life back. It's been really hard."

#PhageTherapy #UTI

https://www.ctvnews.ca/health/first-canadian-trial-successfully-uses-phage-therapy-to-stop-life-threatening-uti-caused-by-superbug-1.6466739?cid=sm%3Atrueanthem%3A%7B%7Bcampaignname%7D%7D%3Atwitterpost%E2%80%8B&taid=64a4ffecd6b4f0000125bd75&utm_campaign=trueAnthem%3A+Trending+Content&utm_medium=trueAnthem&utm_source=twitter

Check out the new episode of our "NewIn" series with Li Deng, Professor of the Prevention of #Microbial #InfectiousDiseases. Her research focuses on #phages, the natural enemies of bacteria: http://go.tum.de/902588

#bacteriophages #antibioticresistance

▶️ https://youtu.be/3k_mJd_HZ_o
🎥 @prolehre

Inching towards using phages as treatment for Mycobacterium abscessus.
#microbiology #phages #antibiotics
https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00304-X/fulltext?dgcid=raven_jbs_aip_email#%20

Happy to say I defended my dissertation "Methods and complexity in phage-bacteria ecology and evolution"!

Much thanks to all those who supported me throughout my PhD.

I'm glad to be sticking around the Turner Lab for another year as a post-doc to continue my work on multispecies phage-bacteria communities

#PhDone #AcademicChatter #AcademicMastodon #Academia #PhD #Ecology #Evolution #Phage #Phages

The May issue is online now!

Articles on the predictive potential of the #microbiome, bacterial #chemotaxis in diseases (cover image), relationship between #phages and endospore formers, #honeybee susceptibility to P. larvae infection and more!

https://www.cell.com/issue/S0966-842X(22)X0006-1

Important read by @marynmck: We're nearing the catastrophic end of the #antibiotic era. It's time to call in the #phages. #medicine #cysticfibrosis #CFaware https://www.wired.com/story/phages-fight-antibiotic-resistant-bacteria/ https://www.wired.com/story/phages-fight-antibiotic-resistant-bacteria/

In the war on bacteria, it’s time to call in the phages - Enlarge (credit: Jacqui VanLiew/Getty Images)

Ella Balasa was ... - https://arstechnica.com/?p=1928916 #antibioticresistance #antibiotics #bacteria #science #disease #phages

Ars Technica: In the war on bacteria, it’s time to call in the phages https://arstechnica.com/?p=1928916 #Tech #arstechnica #IT #Technology #antibioticresistance #antibiotics #bacteria #Science #disease #phages

This seems so cool!

Diverse and Abundant Viruses Exploit Conjugative Plasmids

Natalia Quinones-Olvera, Siân V Owen, Lucy M McCully, Maximillian G Marin, Eleanor A Rand, Alice C Fan, Oluremi J Martins Dosumu, Kay Paul, Cleotilde E Sanchez Castaño, Jillian S Paull, Rachel Petherbridge, Michael Baym

bioRxiv https://doi.org/10.1101/2023.03.19.532758

#phages #microbiology

#ALT4u

A bearded fellow in front of a lectern. Their laptop has a flagellated #bacteria sticker on it. They are presumably saying something like "check-out the cool #research being done on the BASEL #phage collection, what do you want to do with it?"

The large projector screen has a slide on it titled: A field guide for #ecoli #phages describes all major groups (and lots of new findings). There are figures from a 2011 paper with EM, phylogenies, etc displayed (linked above).

@npariente

RT @michelagambino1
🥳🥳 Time for celebrations @LNdsted - published this industrial trial with #Salmonella #phages in a #slaughterhouse 🧫🥓🐖cool collaboration with ISIFoodProtection and @danishcrown to take phages from the lab 🔬to the market 🍗🥙🧀 #foodsafety #OneHealth
https://www.sciencedirect.com/science/article/pii/S0740002023000278

RT @vivek_mutalik
Super thrilled to share our new publication led by @ben_a_adler “Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins” on single strand RNA Fiersviridae #phages https://www.nature.com/articles/s41589-023-01269-7

RT @SarahLebeer
Please join us in the Netherlands at the end of August if you are interested in #lacticacidbacteria, #bacteriocins, #phages, #hostmicrobeinteractions, #genetics & #metabolism. Here is our great president Eddy Smid https://twitter.com/labsymposiumorg/status/1623678301146435585

RT @KintsesLab
Years long hard work has finally borne fruit with our paper out in @NatureMicrobiol! We studied antibiotic resistance #AMR by employing engineered #phages to deliver large DNA libraries into clinical strains together with @ApjokGabor @SysbioS

Read more: https://rdcu.be/c5j34