@medrxivpreprint
The commonly used #antibiotics #amoxicillin, #metronidazole, #piperacillin-tazobactam & #Clindamycin reached levels equivalent to blood within infected pleural fluid.Low penetration of trimethoprim into the pleural space raised concerns about the use of #cotrimoxazole for patients with #Pleuralinfection or parapneumonic effusions.
#Antibiotic #pharmacokinetics in infected #pleuraleffusions
https://www.medrxiv.org/content/10.1101/2023.09.08.23295282v1.full.pdf

#IDMastodon #Viralimmunology #Drugdevelopment @asmicrobiology #Phase II #Clinicaltrial for evaluating the #antiviral activity, safety, efficacy, & #pharmacokinetics of #bemnifosbuvir in ambulatory patients with mild/moderate #COVID19 . Although the study ended early and did not meet the primary efficacy end point, bemnifosbuvir was well tolerated and did not contribute to all-cause mortality. vs placebo

Can clofazimine replace rifampicin in Mycobacterium avium complex lung disease treatment? The brilliant Sandra Salillas has modified the hollow fiber model so we can find out! Exciting! #pharmacokinetics #pharmacodynamics #mycobacteria #tuberculosis #NTM #ntmlungdisease @radboudumc

#Pharmacokinetics/pharmacodynamics of #phage #therapy: a major hurdle to clinical translation - Clinical #Microbiology and Infection

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00046-0/fulltext

Dear #psychiatry folks, do any of you know of a resident or faculty doc interested in #lithium #pharmacokinetics whom I could suggest to the journal as a possible reviewer for the world's shortest article? They're having trouble finding anyone. Thanks. The article is free at
https://f1000research.com/articles/11-779/v1

Dear #psychiatry folks, do any of you know of a resident or clinician interested in #lithium #pharmacokinetics whom I could suggest to the journal as a possible reviewer for the world's shortest article? They're having trouble finding anyone. Thanks. The article is free at
https://f1000research.com/articles/11-779/v1

What this boils down to is using mathematical/statistical models to help explain and predict what the body does to the drug (#Pharmacokinetics, #PK) and what the drug does to the body (#Pharmacodynamics, #PD) - these are often combined to produce #PKPD or #ExposureResponse models.

Pharmacometrics rolls up modeling and simulation for #Pharmacokinetics, #Pharmacodynamics, and #DiseaseProgression, with a focus on populations and variability. A major focus is to understand variability in drug response, which can be predictable (e.g. due to differences in body weight or kidney function) or unpredictable (differences between subjects seem random, but likely reflect a lack of knowledge or data).

https://en.wikipedia.org/wiki/Pharmacometrics