Who still uses #DEX in #ICU?

“Use of #dexmedetomidine in critical-ill patients: is it time to look to the actual #evidence?”

https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04618-z

#CriticalCare #CritCare #FOAMcc #Sedation #Pharmacology

#pharmacology #legal folks - I'm looking for work on sustained release medications where different brands use different mechanics, resulting in different pharmacokinetics (e.g., where a generic delivers on a substantially different curve from an original brand name), especially where that has resulted in reformulation or removal from the market. Any good examples?

AMP has just published!
"First Report of Salmonella Serovar Typhimurium and Monophasic Typhimurium Clinical Isolates Harboring mcr-9 in Portugal"

Letter to the Editor by Leonor Silveira and Ângela Pista, from the Department of Infectious Diseases at Instituto Nacional de Saúde Doutor Ricardo Jorge, in Lisbon.

Full paper available here:
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/20111

#colistin #pharmacology #bacterialdrugresistance #microbialsensitivitytests #salmonellatyphimurium #genetics

#pharmacology @PJOnline_News
A review of the evidence to examine whether exposure to #antihypertensive medicines is linked with #depression.
https://pharmaceutical-journal.com/article/research/do-antihypertensive-medicines-increase-the-risk-of-depression

Scientists may have discovered mechanism behind cognitive decline in aging

https://medicalxpress.com/news/2023-07-scientists-mechanism-cognitive-decline-aging.html

"Bayer said the new research opens the way toward developing drugs and other therapeutic interventions that could normalize the nitrosylation of the protein. He said that holds out the possibility of treating or staving off normal cognitive decline for an unknown period of time."

#Neuroscience #Aging #Pharmacology

In vitro and in vivo characterization of #SARS-CoV-2 #resistance to #ensitrelvir https://www.nature.com/articles/s41467-023-40018-1 #antivirals #research #science #pharmacology

Chemists at University of #Bath synthesise #ibuprofen and #paracetamol (#acetaminophen) from #pine-derived #paper #byproduct, instead of petrochemicals: https://www.bath.ac.uk/announcements/scientists-make-common-pain-killers-from-pine-trees-instead-of-crude-oil/ #science #pharma #pharmacology #waste #environment #FossilFuel

Congratulations to Ryan Moore, a 2020 graduate of our MS program who has been promoted to senior biostatistician on our analytical staff (shown here with professor Leena Choi and senior biostatistician Josh DeClercq). His roles include organizing the Statistical Computing Series, and he was the 2021 winner of our department's Linda Stewart Applied Analysis Report Award for a paper on specialty medication adherence. #clinicaltrials #pharmacology Photo: Donn Jones/VUMC

A PhD position in neuropharmacology to study the mechanism of psilocybin in Basel! Application until 15 juin🧑‍🔬🍄✨

https://jobs.unibas.ch/offene-stellen/phd-position-in-neuropharmacology/06dbf267-933e-4738-9d9e-4633d6734e9d
#psilocybin #psychedelic #research #PhD #science #pharmacology #switzerland #psychedelicscience

Just released: Pharmacology of Encephalitis/Bacterial Meningitis Cheat Sheet by Bailey_Rickett

Download it free at http://www.cheatography.com/bailey-rickett/cheat-sheets/pharmacology-of-encephalitis-bacterial-meningitis/?utm_source=mastodon

Here's their description of it: Pharmacology of Encephalitis and Bacterial Meningitis.

@cheatsheets #CheatSheet #CheatSheets #pharmacology

Just released: Pharmacology of Seizure Disorders Cheat Sheet by Bailey_Rickett

Download it free at http://www.cheatography.com/bailey-rickett/cheat-sheets/pharmacology-of-seizure-disorders/?utm_source=mastodon

@cheatsheets #CheatSheet #CheatSheets #pharmacology

Just released: Pharmacology of Ischemic Stroke Management Cheat Sheet by Bailey_Rickett

Download it free at http://www.cheatography.com/bailey-rickett/cheat-sheets/pharmacology-of-ischemic-stroke-management/?utm_source=mastodon

Here's their description of it: Pharmacology of Ischemic Stroke Management

@cheatsheets #CheatSheet #CheatSheets #pharmacology

Just released: Pharmacology of Alzheimer's Disease Cheat Sheet by Bailey_Rickett

Download it free at http://www.cheatography.com/bailey-rickett/cheat-sheets/pharmacology-of-alzheimer-s-disease/?utm_source=mastodon

@cheatsheets #CheatSheet #CheatSheets #pharmacology

"Stealth Liposomes" sounds pretty dope, ngl.

Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511

#Science #Research #Alzheimers #pharmacology
http://biorxiv.org/cgi/content/short/2023.05.02.539100v1?rss=1

Just released: Top 300 Cheat Sheet by chautommy93

Download it free at http://www.cheatography.com/chautommy93/cheat-sheets/top-300/?utm_source=mastodon

Here's their description of it: Top 300 Rx Drugs; Brand - Generic - Indication

@cheatsheets #CheatSheet #CheatSheets #pharmacology

Lol:
"Wastewater study finds 18 new psychoactive drugs"
"A testing program shows a string of new psychoactive substances in widespread use across the globe. Scientists believe criminals are developing substances slightly altered from illegal drugs to stay ahead of the law."
https://www.dw.com/en/wastewater-study-finds-18-new-psychoactive-drugs/a-65474560
#drugs #science #pharmacology #wastewater

Just released: Pharmacology of Parkinson's Disease Cheat Sheet by Bailey_Rickett

Download it free at http://www.cheatography.com/bailey-rickett/cheat-sheets/pharmacology-of-parkinson-s-disease/?utm_source=mastodon

@cheatsheets #CheatSheet #CheatSheets #pharmacology

Just released: Migraine Pharmacology Cheat Sheet by Bailey_Rickett

Download it free at http://www.cheatography.com/bailey-rickett/cheat-sheets/migraine-pharmacology/?utm_source=mastodon

@cheatsheets #CheatSheet #CheatSheets #pharmacology

Why are medical units so bad ?

what the f*ck is an mcL ?

I'm guessing 1/1000thof a cL, which must be 1/100th of a liter

so 1/1000th of 10mL
or 10uL ?

wtf

merck manual on line
https://www.merckmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia

#scicomm #pharmacology #medicine

Curing disease is the hot new field for AI talent - One of the many exciting and appropriate uses of new #AI technologies. As a former health care professional who is very disillusioned with the current state of health care delivery in the US and third world nations, I am excited about the prospects of AI-assisted diagnostics, robotic surgery and new drug development. It is unfortunate however that the corporate medical/pharma complex will reap untold and likely obscene profits from these efforts. Which is why I support public university research and #medicareforall https://www.semafor.com/article/04/21/2023/curing-disease-is-the-hot-new-field-for-ai-talent #publichealth #medicine #pharmacology #healthcare #disease