#IDMastodon #pharmaimmunology #Immunology Understanding the anti-inflammatory impact of #dexamethasone on the pathways contributing to cytokine hyperresponsiveness observed in severe manifestations of #COVID19, incl type I/II IFN signaling. Dexamethasone could have adverse effects in Mild #COVID19 by inhibiting IFN responses in early stages of the disease, whereas it exhibits beneficial effects in patients with severe clinical phenotypes by efficiently diminishing cytokine hyperresponsiveness.