A very nice review on RNA granules from Geraldine Seydoux's lab at Genes & Development.

"RNA granules: functional compartments or incidental condensates?"

#RNA #granules #mRNA #phaseseparation #translation #splicing #Pbodies #StressGranules
#GermGranules

https://genesdev.cshlp.org/content/37/9-10/354.abstract

The final 'First person' interview in our current Issue is with Vaishna Vamadevan on her PhD project in Subbareddy Maddika's lab at Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India, investigating the role of ubiquitylation in regulating various cellular events:
https://journals.biologists.com/jcs/article/135/24/jcs260861/285952/First-person-Vaishna-Vamadevan
#cellbiology #research #ubiquitin #phaseseparation #science #sciencemastodon #earlycareerresearcher

Farias &co show that stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells. Initial peer review @ReviewCommons #openaccess: https://journals.biologists.com/jcs/article/135/23/jcs260294/285214/Stress-induced-phase-separation-of-ERES-components
#cellbiology #research #openscience #phaseseparation #ERstress

RT @Co_Biologists
Register now for On Demand Access to @KeystoneSymp #BiomolecularCondensates: Emerging Cellular and Biophysical Roles, this Jan/Feb to explore emerging #PhaseSeparation #GenomeOrganization research #KSBioCondensates23
https://hubs.la/Q01s_yPS0

#Biomolecular #condensates and #PhaseSeparation are getting significant attention in the #signaling field. Here are two papers implicating condensates in #Hippo signaling. In the first, #cancer-initiating cells adopt a glycogen storing mode that blocks Hippo signaling through phase separation. In the second, antagonizing condensates control Hippo signaling without dissolution, via multiphase coalescence.
https://www.sciencedirect.com/science/article/pii/S0092867421011752
https://www.sciencedirect.com/science/article/pii/S0092867422012557

RT @AndreaMusacchi1@twitter.com

(1/3) Thank you Michele. To be sure, my statements on #phaseseparation reflect the puzzlement of scores of researchers who do exceptional mechanistic work, and who see oversimplification replace established facts and practices. @ElieDolgin@twitter.com portrayed my critique as an https://twitter.com/paganolab/status/1596285089121325057

🐦🔗: https://twitter.com/AndreaMusacchi1/status/1596406862001233921