The EMBO Journal · @embojournal
427 followers · 145 posts · Server sciencemastodon.com

The EGFR RPTPγ is a -regulated suppressor of promigratory signaling
Maitreyi Joshi, Philippe Bastiaens et al show that is coupled to autocatalytic, ligandless by a ROS-mediated toggle-switch, enabling ultrasensitive EGFR activation at the plasma membrane
embopress.org/doi/10.15252/emb

#phosphatase #redox #rptpγ #egfr #phosphorylation

Last updated 2 years ago

StructBiolCommunications · @ActaCrystF
44 followers · 52 posts · Server mstdn.science

The first serial synchrotron crystallography structure of apo PTP1B indicates a degree of allosteric decoupling that adds nuance to the previously reported paradigm of allostery in this protein   doi.org/10.1107/S2053230X22011

#Xraycrystallography #phosphatase #allostery #openaccess

Last updated 2 years ago

The EMBO Journal · @embojournal
360 followers · 53 posts · Server sciencemastodon.com

Happy New Year 2023!
Our first issue brings:

conformation changes in cold response

Mammalian controls exit in cells

release via -mediated - bridging

TNFα and cortical protein during

...and more:
embopress.org/toc/14602075/202

#calreticulin #cdc14 #phosphatase #stemness #pluripotent #exosomal #interleukin #iqgap1 #gasdermin #escrt #microglial #phosphorylation #sleep

Last updated 2 years ago