The EMBO Journal · @embojournal
427 followers · 145 posts · Server sciencemastodon.com
The EGFR #phosphatase RPTPγ is a #redox-regulated suppressor of promigratory signaling
Maitreyi Joshi, Philippe Bastiaens et al show that #RPTPγ is coupled to autocatalytic, ligandless #EGFR #phosphorylation by a ROS-mediated toggle-switch, enabling ultrasensitive EGFR activation at the plasma membrane
https://www.embopress.org/doi/10.15252/embj.2022111806
#phosphatase #redox #rptpγ #egfr #phosphorylation
StructBiolCommunications · @ActaCrystF
44 followers · 52 posts · Server mstdn.science
The first serial synchrotron crystallography structure of apo PTP1B indicates a degree of allosteric decoupling that adds nuance to the previously reported paradigm of allostery in this protein #XRayCrystallography #Phosphatase #Allostery #openaccess https://doi.org/10.1107/S2053230X22011645
#Xraycrystallography #phosphatase #allostery #openaccess
The EMBO Journal · @embojournal
360 followers · 53 posts · Server sciencemastodon.com
Happy New Year 2023!
Our first issue brings:
#Calreticulin conformation changes in cold response
Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells
#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging
#Microglial TNFα and cortical protein #phosphorylation during #sleep
...and more:
https://www.embopress.org/toc/14602075/2023/42/1
#calreticulin #cdc14 #phosphatase #stemness #pluripotent #exosomal #interleukin #iqgap1 #gasdermin #escrt #microglial #phosphorylation #sleep