I'm thrilled to have been a small part of an amazing team to work on uncovering how plants regulate lateral root angles using auxin, PIN auxin transporters, and phosphorylation status. #auxin #phosphorylation #cellbiology #gravitropism https://www.nature.com/articles/s41477-023-01478-x
#auxin #phosphorylation #cellbiology #gravitropism
TOR-mediated Ypt1 #phosphorylation regulates autophagy initiation complex assembly
The Rab #GTPase #Ypt1 serves as a bridge that connects environmental sensing to the formation of the #autophagy initiation complex.
#phosphorylation #gtpase #ypt1 #autophagy
#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis
#phosphorylation #Mitosis #cellcycle #kif4a #cenpe #prc1 #microtubule #midbody #cytokinesis
Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?
Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation
#cul4a #cul4b #Ubiquitin #ligases #mitotic #phosphorylation #dcaf #cytoskeleton
#Phosphorylation of phase-separated #p62 bodies by #ULK1 activates a #redox-independent stress response
Masaaki Komatsu, Nobuo Noda, Yoshinobu Ichimura and colleagues
#phosphorylation #p62 #ulk1 #redox
How mature are the identification algorithms for top-down #proteomics? If we use two different algorithms on the same data, do we see the same proteoforms? I was recently lucky enough to invest two whole years in top-down #bioinformatics, courtesy of Julia Chamot-Rooke. Kyowon Jeong invested some serious time to teach me about #deconvolution, too! We feature new data from Mowei Zhou for #phosphorylation proteomics.
https://doi.org/10.1021/acs.jproteome.2c00673
#proteomics #bioinformatics #deconvolution #phosphorylation
The EGFR #phosphatase RPTPγ is a #redox-regulated suppressor of promigratory signaling
Maitreyi Joshi, Philippe Bastiaens et al show that #RPTPγ is coupled to autocatalytic, ligandless #EGFR #phosphorylation by a ROS-mediated toggle-switch, enabling ultrasensitive EGFR activation at the plasma membrane
https://www.embopress.org/doi/10.15252/embj.2022111806
#phosphatase #redox #rptpγ #egfr #phosphorylation
A new proteomic workflow establishing interdependencies between protein #phosphorylation & complex formation is applied to the signal integrator & Hippo pathway effector YAP1 ➡️ http://bit.ly/3mJ4W0t
Matthias Gstaiger @eth_en
#proteomics #interactome #ProteinProteinInteractions #CellSignaling
#phosphorylation #proteomics #interactome #proteinproteininteractions #cellsignaling
Scientists uncover #phosphorylation-driven #auxin #signaling pathway for #seed size regulation in #rice.
#biotechnology #agriculture #TGW3 #OsIAA10
https://phys.org/news/2023-03-scientists-uncover-phosphorylation-driven-auxin-pathway.html
#phosphorylation #auxin #signaling #seed #rice #biotechnology #agriculture #tgw3 #osiaa10
Li et al. report that #phosphorylation of the serine palmitoyltransferase LCB1 subunit stimulates its activity and modulates #sphingolipid #biosynthesis in #Arabidopsis.
https://doi.org/10.1111/jipb.13461
@wileyplantsci
#PlantScience #JIPB #signaling #PlasmaMembrane
#phosphorylation #sphingolipid #biosynthesis #arabidopsis #plantscience #JIPB #signaling #plasmamembrane
How do #nutrient-starved cells preserve a basal supply of dormant #ribosomes?
Michael Hall and colleagues (Biozentrum Basel) identify conserved #TORC1 #phosphorylation and inhibition of ribosome-binding factor #Stm1/#SERBP1 in #yeast and human cells
https://www.embopress.org/doi/10.15252/embj.2022112344
#nutrient #ribosomes #torc1 #phosphorylation #stm1 #yeast
Happy New Year 2023!
Our first issue brings:
#Calreticulin conformation changes in cold response
Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells
#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging
#Microglial TNFα and cortical protein #phosphorylation during #sleep
...and more:
https://www.embopress.org/toc/14602075/2023/42/1
#calreticulin #cdc14 #phosphatase #stemness #pluripotent #exosomal #interleukin #iqgap1 #gasdermin #escrt #microglial #phosphorylation #sleep
#Phytosulfokine #peptide optimizes #plant growth and defense via #glutamine #synthetase GS2 #phosphorylation in #tomato
Shuting Ding et al. Zhejiang University
#phytosulfokine #peptide #plant #glutamine #synthetase #phosphorylation #tomato
Krystal Timón Pérez, Jacopo Scrofani and Isabelle Vernos show that #phosphorylation of #NEDD1 at S411 is essential for the coordination of #microtubule nucleation during #mitosis:
https://journals.biologists.com/bio/article/11/11/bio059474/282931
#CellScience #CellCycle #Biology #Science #AcademicMastodon #BiologyOpen
#phosphorylation #nedd1 #microtubule #mitosis #cellscience #cellcycle #biology #Science #AcademicMastodon #biologyopen
🚨 Don't miss this brand new article in Comms Biol spearheaded by Johanna Kaufmann exemplifying fast and easy detection of #GPCR #phosphorylation in 96-well format.
https://www.nature.com/articles/s42003-022-04135-9
Antibody phosphospecificity was confirmed by #peptide microarrays in our lab. Big thx and congrats to all co-authors! 😄
#research #collaboration #biophysics
Phosphospecific antibodies available at: https://7tmantibodies.com/
#GPCR #phosphorylation #peptide #research #collaboration #biophysics