Excited for participating in this #spatialtranscriptomics #Visium platform study with an expert team from @NICHD_NIH, in the first step of studying the spatial biology of #pituitary corticotroph tumors, revealing their heterogeneity.

https://www.medrxiv.org/content/10.1101/2023.08.04.23293576v1

Very happy to share our newly published #article "Sex differences in pituitary corticotroph excitability".

It is well known that sex differences exist in stress-related disorders, with women having twice the lifetime rate of depression compared to men and most anxiety disorders.

Corticotroph cells in the pituitary gland are a key player in the generation of hormonal stress responses. However, their contribution to sexually differential responses of the stress axis (which might underlie differences in stress-related disorders) is very poorly understood.

We found sex differences in the electrical activity of these cells, which could be related to differences in their gene expression pattern.

These findings shed light on the cellular mechanisms underlying sex differences in stress responses, contributing to a better understanding of stress-related disorders and potential avenues for diagnosis and treatment.

#stress #pituitary #research #electrophysiology #physiology #corticotrophs #hpa #anxiety

https://www.frontiersin.org/articles/10.3389/fphys.2023.1205162/full

After sufficient decades to finally have #healthcare take my #medication needs seriously, and showing the endo my box of overseas HGH (Gentropin, only $14/d at my dose!😭), I finally have a $10/90-days prescription and a dose pen for injections. #endocrinology #hormone #pituitary

In a #casestudy publised in @NEJM, Christopher Hong, MD, and Bulent Omay, MD, say a #multidisciplinary approach was key in treating #pituitary #apoplexy in an 81-year-old patient. #medmastodon https://medicine.yale.edu/news-article/case-study-of-pituitary-apoplexy-patient-published-in-new-england-journal-of-medicine/

This is what #remission looks like when treating a #pituitary #tumor.

I'll never know exactly when or why it started taking over that part of my #endocrine system but it's nice to know that I can ask for the right #medication when #kaiserpermanente #doctors don't know what to do or want to "see if it will get bigger". No thanks. I'd prefer a 13.6x reduction to the middle of reference range for this hormone.

Now, maybe they'll stop asking stupid questions when I ask for "uncommon labs". 🤦🏼‍♀️🤯

Best meetings of the year @bnes_uk@twitter.com and this CPC

Day long case based discussions and problem solving, keynotes and updates

Highly recommended #neurosurgery #pituitary #endocrinology

Pre and postoperative mri of a px w\ a pituitary adenoma which was succesfully treated with a complete extracapsular endoscopic resection.

#nsgy #skullbase #extracapsular #pituitary #adenoma

RT @ChantalBritt@twitter.com

Great @VirusesImmunity@twitter.com talk about #LongCovid:
#autoimmunity most likely not driver
focus on tissue damage, viral reservoirs, dysbiosis & #EBV #VZV reactivation
cortisol levels lower (defect in #hypothalamus and/or #pituitary?)
more antibodies, less functional to neutralise SARS2

🐦🔗: https://twitter.com/ChantalBritt/status/1593618574807031811

Managed to attend the @NHSGIRFT@twitter.com Endocrinology session at #SfEBES2022 with Prof Wass presenting on #pituitary surgery

It was an excellent session and thanks to #SfEBES2022 for the invite - also really nice to catch up with my many endocrinology friends and colleagues #craniopharyngioma #pituitary

RT @hormone_doc@twitter.com

Some of the most complex patients we look after. Disease management and monitoring , hormone replacement, Late effects of treatments Inc RT/PBT #SfEBES2022

🐦🔗: https://twitter.com/hormone_doc/status/1592570101274120192

🔥 Throwbacks Headlines: The #thyroid also contained a high number of proviral remnants, as did the #pituitary gland, which is a bean-shaped structure in your brain that produces #hormones. https://maddoctors2020.blogspot.com/2022/10/throwbacks-headlines-thyroid-also.html

@nick can we request emoji? Wishlist: #thyroid #adrenal #diabetestech (pump,CGM) & if you want a serious challenge a #pituitary 😃 :pancreas:

I thought I would share this image, which I took a while ago, but that I really like! This is a #pituitary gland where cells expressing a protein called proopiomelanocortin (POMC for short) have been coloured in green. You can see two groups of cells; a very packed band in the middle and some sparse cells on the sides. The first are called melanotrophs, and they are important in determining skin and fur colour. The sparse cells on the sides are called corticotrophs (and that's what I am studying at the moment!) and they are important for the response to #stress . They secrete an #hormone called ACTH which stimulates the production of the stress hormone cortisol from the adrenal gland. At the moment we are trying to understand what happens to this cells after the body is exposed to stress for a prolonged amount of time. #scicomm #biology #science #physiology #microscopy

Hello everyone! Here's my #introduction! I am a senior lecturer at the University of Edinburgh, mostly teaching biomedical #ImageAnalysis and #DataScience ( #machinelearning #statistics and all that jazz) using #rstats and #python. My research interests revolve around #neuroendocrinology that is, understanding how your brain controls the production of hormones in your body. I am particularly interested in the role of #heterogeneity of cells in the #pituitary gland and how that contributes to generating the right pattern of hormones at the right time!