A preeclampsia cure?

"Our study identifies cis P-tau as a crucial culprit and biomarker for preeclampsia."

“cis P-tau antibody efficiently depleted the toxic protein in the blood and placenta, and corrected all features associated with preeclampsia in mice….elevated blood pressure, excessive protein in urine and fetal growth restriction, among others, were eliminated and pregnancy was normal,"

#preeclamspia #placenta #pregnancy #reproduction #Canada

https://medicalxpress.com/news/2023-09-preeclampsia.html

Embryo-uterine interaction coordinates mouse embryogenesis during implantation (open access)
“adhesion between the trophoblast and the uterine matrix is required for in utero-like transition of the blastocyst to the egg cylinder.”

#EmbryonicDevelopment #Development #Placenta #trophoblast #DevBio

https://www.embopress.org/doi/full/10.15252/embj.2022113280

“Indeed, doctors discovered that some #stillbirths resulted from #COVID19 directly infiltrating the #placenta, a condition they named #SARSCoV2 #placentitis. Cases were found even in people whose COVID-19 symptoms were mild or nonexistent.”

And the Nature paper itself
#placenta #trophoblasts #pregnancy #Science #medicine
https://www.nature.com/articles/s41586-023-06298-9

And the open access Nature Cell Biology paper
#placenta #COVID19 #pregnancy

https://www.nature.com/articles/s41556-023-01182-0

How the virus that causes COVID-19 can infect and damage the placenta.

SARS-CoV-2 infection caused significant reduction in the survival and differentiation of syncytiotrophoblast cells, which led to lower production of the human chorionic gonadotropin hormone (hCG) - needed for early pregnancy maintenance.
#pregnancy #placenta #medicine #science #ReproSci #COVID19

https://medicalxpress.com/news/2023-07-covid-placenta-lab-grown-placental-tissue.html

COVID-19 during pregnancy damages the placenta's immune response to further infections https://www.news-medical.net/news/20220919/COVID-19-during-pregnancy-damages-the-placentas-immune-response-to-further-infections.aspx https://www.news-medical.net/news/20220919/COVID-19-during-pregnancy-damages-the-placentas-immune-response-to-further-infections.aspx?s=01 “But what we're seeing now is that the #placenta is vulnerable to #COVID19, and the infection changes the way the placenta works, and that in turn is likely to impact the development of the #fetus,"

"Our study suggests that babies born to mothers infected with COVID-19 at any point during their #pregnancy will need to be monitored as they grow up," she said.

And the paper itself:
“identify GATA3, OCT4, KLF4 and MYC (GOKM) as a combination of factors that can generate functional human induced trophoblast stem cells (hiTSCs) from fibroblasts.”
#placenta #StemCells
https://www.nature.com/articles/s41467-023-39104-1

Really interesting findings.
#placenta #skin #stemcells #medicine #science #scicomm #DevBio #reproduction

https://medicalxpress.com/news/2023-06-reprogrammed-skin-cells-human-placenta.html

🔵 Inserzione velamentosa del cordone ombelicale: cos'è e perché può portare alla morte del feto durante la gravidanza?

👉 Leggi l’articolo: https://medicinaonline.co/2022/12/26/inserzione-velamentosa-del-cordone-ombelicale/

✅ #gravidanza #cordone #feto #morte #placenta #utero #cervice #parto #maternità #parto #prematuro #EmilioAlessioLoiacono #MedicinaOnLine

Myc and the placenta.
“These data reveal Myc is essential for polyploidy to support normal placental development, thereby preventing premature senescence. “
#placenta #Myc #Trophoblast #senescence #reproduction #DevBio #Science
https://journals.biologists.com/dev/article/150/11/dev201581/316006/Myc-promotes-polyploidy-in-murine-trophoblast

An amazing organ: The Placenta
#placenta #pregnancy #reproduction #science #scicomm

https://www.theguardian.com/science/2023/jun/03/gene-genius-placenta-project-unlocking-secrets-of-our-cells

A new study has discovered that the #placenta plays a considerably larger role in the development of sickness than previously thought

https://www.hindustantimes.com/science/schizophrenia-research-studies-mental-health-news-genetic-risk-of-schizophrenia-science-news-101684663184706.html #press

May is Preeclampsia Awareness Month.
More information on this can be found at:
https://www.preeclampsia.org/AwarenessMonth
#preeclampsia #pregnancy #placenta #WomensHealth #ReproSci #Reproduction #Canada #USA

RT @davislaundon
Pleased to announce our Methods in Cell Biology #vEM chapter 'Correlative multiscale microCT-SBF-SEM imaging of resin-embedded tissue' is now out!

Below is an example of our workflow used for multiscale imaging of a sample of horse #placenta

https://authors.elsevier.com/a/1guXq,25QIopEv

New placenta paper: “…data provide a comprehensive analysis of postimplantation trophoblast differentiation that can be used to inform the design of experimental models of the human placenta in early pregnancy.”
#placenta #pregnancy #trophoblast #ReproSci #reproduction #Science #MedMastodon

https://www.nature.com/articles/s41586-023-05869-0

RT @SamanthaLWilson
I have funded MSc/PhDs available in my lab. Please contact me if you are interested in computational bio, genomics, epigenomics, pregnancy and placental development.

Check out http://wilsonpregnancylab.com for more info! And please RT

#compbio #bioinformatics #genomics #placenta

With the great interest in our Canadian #Placenta Webinar in December, we are launching a monthly Canadian virtual placenta seminar series. Please contact myself or @amy_inkster to get on the email list, and please sign up to present here - https://docs.google.com/spreadsheets/d/1kqL7R2TyMwBowLyWWw4tgsKJ35lUeJ6K-ufz_6V0Uz4/edit#gid=0

Please RT!

🔵 Distacco di placenta: cos'è, cosa lo causa e perché può mettere a rischio la vita della madre e del feto?

👉 Leggi l’articolo: https://medicinaonline.co/2023/02/20/distacco-placenta/

✅ #placenta #gravidanza #maternità #feto #ostetricia #EmilioAlessioLoiacono #MedicinaOnLine

Latest from AJOG. “Changing levels of sFlt-1 and PlGF are indicative of placental dysfunction and are strongly associated with the risk of spontaneous preterm birth, especially when combined with slower fetal femur length growth.
#placenta #PreTermBirth #pregnancy #ReproSci #MedMastodon #Science

https://www.ajog.org/article/S0002-9378(23)00077-7/fulltext