20‑Valent #Pneumococcal Conjugate #Vaccine: #Pediatric First Approval

📌20‑valent pneumococcal conjugate vaccine (PCV20; Prevnar 20®; Apexxnar®) is a pneumococcal conjugate vaccine (PCV) for active immunization for the prevention of pneumococcal infections.

📌PCV20 has a similar structure and formulation to PCV13, with the addition of polysaccharides to target seven further S. pneumoniae serotypes (8, 10A, 11A, 12F, 15B, 22F and 33F).

https://link.springer.com/article/10.1007/s40272-023-00584-9

Dynamics of invasive #pneumococcal disease in #infants < 2 years old following #PCV7/13 implementation using two infant and a booster dose schedule

#FactCheck: NO Proof #Pneumococcal #Vaccine Causes #Autism In #Children
https://leadstories.com/hoax-alert/2023/05/fact-check-pneumococcal-vaccine-does-not-cause-autism.html

Reductions in #Childhood #Pneumonia Mortality After #Vaccination in the 🇺🇸

#pneumococcal #vaccine

📌 The universal introduction of #PCV7, and later #PCV13, for children 0-59 months old in the United States was associated with decreases in mortality due to all-cause pneumonia.

https://pubmed.ncbi.nlm.nih.gov/37235761/

RT @AAPAorg
PAs and #HCP: Brush up on the latest @CDCgov ACIP immunization recommendations for #pneumococcal vaccines in your adult patients. Earn free CME in this self-paced module. https://bit.ly/3JXegpl #medtwitter #IPD

#IDMastodon @medrxivpreprint
#Clinicalinvestigation current study suggest that #pneumococcal carriers may have an increased risk of #SarsCoV2 infection and high pneumococcal abundances .16S abundances may be associated with elevated #viralloads and delayed clearance of #SarsCoV2 infection.
📌 https://www.medrxiv.org/content/10.1101/2023.02.20.23286191v1
📌 https://www.medrxiv.org/content/10.1101/2023.02.20.23286191v1.full.pdf

Protecting against #Pneumonia:how is your country doing)

‘New #Pneumococcal Atlas reveals disparities across Europe: older people, and those in Eastern Europe, are more likely to miss out’

https://www.vaccinestoday.eu/stories/protecting-against-pneumonia-how-is-your-country-doing/

CDC adds #Covid19 shots to list of routine #vaccines for #kids and #adults

📌 Key changes to the schedules include Covid-19 primary vaccine series and booster dose; updated guidance on #flu and #pneumococcal vaccines; and new vaccines for #measles, #mumps, and #rubella (MMR) and for #hepatitis B.

📌 The schedule also recommends additional doses of MMR vaccine during a mumps outbreak and administering inactivated polio vaccine in adults at increased risk for exposure.

https://edition.cnn.com/2023/02/09/health/vaccine-recommendations-wellness/index.html

#Pneumococcal #capsule expression is controlled through a conserved, distal cis-regulatory element during infection | PLOS #Pathogens

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011035

Experimental #Evolution In Vivo To Identify Selective Pressures during #Pneumococcal #Colonization | mSystems

https://journals.asm.org/doi/10.1128/mSystems.00352-20

#Pneumococcal Dz, a thread tweetorial. As we are now deep in respiratory virus season, don’t forget strep pneumonia or pneumococcus!

Read this quick and informative thread hosted by @AAPAorg.

#PhysicianAssociate
American Aca…https://lnkd.in/gy_dk76r https://lnkd.in/g_qFafYz

RT @AAPAorg
PAs and #HCPs: Today, we’re talking about #Pneumococcal Disease. (a🧵-- 1/14)

Need a quick update on Pneumococcal disease? What you didn’t know you needed to know ☺️😉

#MedTwitter #PATwitter #NPTwitter #tweetorial
---
RT @AAPAorg
PAs and #HCPs: Today, we’re talking about #Pneumococcal Disease. (a🧵-- 1/14)
https://twitter.com/AAPAorg/status/1604913723025641474

Got my #covid-19 #pfizerbivalent and my #pneumococcal conjugate #pcv20 #vaccines yesterday and boy are my arms tired.

That punchline isn't as funny as I remember it.

👉 In 2019, human rotavirus vaccine (HRV) and pneumococcal polysaccharide protein D-conjugate vaccine (PHiD-CV) together averted

📌 nine cases of severe disease each minute

and

📌 one child death every 4 minutes

in Gavi-supported countries

#Rotavirus
#Pneumococcal
#Vaccine
#Gavi (https://www.gavi.org)

https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2135916

Cost-effectiveness of 20-valent #pneumococcal conjugate vaccine in Denmark compared with PPV23

📌 Vaccination with PCV20 reduced the incidence and mortality of pneumococcal diseases in Danish adults compared to PPV23.
📌 This reduction has the potential to reduce the financial burden related to managing diseases while also increasing public health.

https://www.tandfonline.com/doi/full/10.1080/13696998.2022.2152235

Interested to hear from anyone who knows about prevention of #pneumococcal disease in older people (including those with #dementia).
Is the newer 20-valent #vaccine worth supporting greater access to?
I've seen a US report from January which seemed to suggest they were good value and more effective than currently used 13-valent ones.

Should the UK be using these to prevent outbreaks in care homes?

https://www.cdc.gov/mmwr/volumes/71/wr/mm7104a1.htm

#pneumonia #infection #respiratory #publichealth

Predicting vaccine effectiveness against invasive #pneumococcal disease in #children using immunogenicity data

https://www.nature.com/articles/s41541-022-00538-1.pdf