Structural biology insights into a #Polycomb complex and its inhibition. Structural basis for inactivation of PRC2 by G-quadruplex RNA https://www.biorxiv.org/content/10.1101/2023.02.06.527314v1

PROTAC degraders Rock! Read this application to the #Polycomb BMI and RING1B proteins:
Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy.
https://doi.org/10.1002/advs.202205573

New discoveries about #Polycomb #EZH2 function in #MultipleMyeloma and a therapeutic avenue here:
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023). https://doi.org/10.1038/s41388-023-02618-5

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473

A #oncohistone, #Polycomb #SWISNF interplay provides a possible avenue for treatment of #pediatric gliomas: #BAF Complex Maintains #Glioma Stem Cells in Pediatric #H3K27M #Glioma - https://doi.org/10.1158/2159-8290.CD-21-1491 @CD_AACR

#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296

How is a lung #cancer driven by loss of #Polycomb : Polycomb deficiency drives a FOXP2-high aggressive state targetable by #epigenetic inhibitors. https://rdcu.be/c3Zdu

A #genome-wide computational approach to define #microRNA-#Polycomb/trithorax gene regulatory circuits in #Drosophila https://www.sciencedirect.com/science/article/pii/S0012160622002378

1st weekly digest of #GeneRegulation papers:

🧬#TranscriptionFactor atlas of differentiation https://www.sciencedirect.com/science/article/pii/S0092867422014702

🧬 #TFbinding directed heterochromatin (#ZFP462) https://www.nature.com/articles/s41556-022-01051-2

🧬#3Dgenome organisation of nuclear speckles & splicing https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1

🧬 Nuclear partitioning by charge blocks (#MED1, #PolII) https://www.sciencedirect.com/science/article/pii/S0092867422015264

🧬 Transient loss of #Polycomb induces an #epigenetic cancer fate https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1

🧬 RGT: a toolbox for NGS analysis https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1

RT @giacomo_cavalli
#Epigenetic Alert: we just posted a bioRxiv manuscript of exceptional interest (we think) !
Transient loss of #Polycomb components induces an #epigenetic #cancer fate http://dlvr.it/SgPSrc
Brief thread follows, we are looking for feedback, thank you in advance!

RT @giacomo_cavalli@twitter.com

#Epigenetic Alert: we just posted a bioRxiv manuscript of exceptional interest (we think) !
Transient loss of #Polycomb components induces an #epigenetic #cancer fate http://dlvr.it/SgPSrc
Brief thread follows, we are looking for feedback, thank you in advance!

🐦🔗: https://twitter.com/giacomo_cavalli/status/1611072439852621831

RT @giacomo_cavalli@twitter.com

#Epigenetic Alert: we just posted a bioRxiv manuscript of exceptional interest (we think) !
Transient loss of #Polycomb components induces an #epigenetic #cancer fate http://dlvr.it/SgPSrc
Brief thread follows, we are looking for feedback, thank you in advance!

🐦🔗: https://twitter.com/giacomo_cavalli/status/1611072439852621831

RT @giacomo_cavalli@twitter.com

Stepwise #signalling + #chromatin regulation to drive cell #differentiation directionality! #PLOSBiology: ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the #polycomb repressive complex https://dx.plos.org/10.1371/journal.pbio.3000221

🐦🔗: https://twitter.com/giacomo_cavalli/status/1602712549673390080

A new mechanism for #Polycomb-induced breast #cancer #metastasis: EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis. https://rdcu.be/c1ya0

RT @conwayer1@twitter.com

Still plenty of time left to apply for this @scienceirel@twitter.com funded post-doc fellow position in my group @UCD_Conway@twitter.com Please share and RT 🙏

#jobfairy #epigenetics #CancerResearch #phdlife #PhDone #enhancers #chromatin #polycomb https://twitter.com/conwayer1/status/1590753587776303104

🐦🔗: https://twitter.com/conwayer1/status/1602628608681558016

A new mechanism for #Polycomb-induced breast #cancer #metastasis: EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis. https://rdcu.be/c1ya0

A decline in ERK1/2 signaling promotes #neural #differentiation by regulating #chromatin accessibility & #polycomb protein occupancy at neural genes in mouse embryo & in human neural precursors @katestorey27 @metzisv @briscoejames &co #PLOSBiology https://plos.io/3OYGPF4

A decline in ERK1/2 signaling promotes #neural #differentiation by regulating #chromatin accessibility & #polycomb protein occupancy at neural genes in mouse embryo & in human neural precursors @katestorey27 @metzisv @briscoejames &co #PLOSBiology https://plos.io/3OYGPF4

RT @PLOSBiology@twitter.com

A decline in ERK1/2 signaling promotes #neural #differentiation by regulating #chromatin accessibility & #polycomb protein occupancy at neural genes in mouse embryo & in human neural precursors @katestorey27@twitter.com @metzisv@twitter.com @briscoejames@twitter.com &co #PLOSBiology https://plos.io/3OYGPF4

🐦🔗: https://twitter.com/PLOSBiology/status/1598676357323452418

A decline in ERK1/2 signaling promotes #neural #differentiation by regulating #chromatin accessibility & #polycomb protein occupancy at neural genes in mouse embryo & in human neural precursors @katestorey27 @metzisv @briscoejames &co #PLOSBiology https://plos.io/3OYGPF4