Although the first total synthesis of taxol was accomplished nearly 30 years ago, its complex structure still motivates researchers to invent new synthetic routes. Now, Masayuki Inoue and co-workers (University of #Tokyo #Japan) published a radical-based approach to the #polyketide in the journal #AngewandteChemie

https://onlinelibrary.wiley.com/doi/10.1002/anie.202219114

@chemistry #chemistry #totalsynthesis #orgchem

Nowadays, a lot of total #synthesis projects include terpenes with a C-H functionalization strategy.

In contrast, Alois Fürstner and co-workers (MPG Mülheim) recently presented their synthesis of prorocentin, a complex #polyketide, in #JACS featuring up-to-date transformations and beautifully designed synthetic routes. I added this synthesis now to my collection, have a look 👇

https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/first-total-synthesis-and-structural-revision-of-prorocentin-a-furstner-2023

#chemistry @chemistry