Søren Grubb · @Grubb
20 followers · 27 posts · Server mas.to
Conclusion: In the #Brain 🧠, #Microvasculature is not #Innervated like in #PeripheralTissue. #PrecapillarySphincters and/or #FirstOrderCapillaries are central to #NeurovascularCoupling, which may be enhanced by perpendicular alignment of #NeuronalProcesses (12/15)
#neuronalprocesses #neurovascularcoupling #firstordercapillaries #precapillarysphincters #peripheraltissue #innervated #microvasculature #brain
Søren Grubb · @Grubb
20 followers · 27 posts · Server mas.to#MyoendothelialJunctions are 🔗s between #MuralCells and #Endothelia, elsewhere separated by the #BasementMembrane. I show how #Brain #PrecapillarySphincters are 🔥spots for these junctions (yellow dots), like Rhodin showed in 🐇 #PeripheralTissue: https://tinyurl.com/cm8chj56 (7/15)
#peripheraltissue #precapillarysphincters #brain #basementmembrane #endothelia #muralcells #myoendothelialjunctions
Søren Grubb · @Grubb
20 followers · 27 posts · Server mas.to
‼️Importantly, #PrecapillarySphincters exist where a #Capillary branches from a much larger #Arteriole (≈upper cortical layers) but not when there is a more gradual transition (≈lower cortical layers). (3/15)
#arteriole #capillary #precapillarysphincters
Søren Grubb · @Grubb
20 followers · 24 posts · Server mas.to
Conclusion: In the #Brain 🧠, #Microvasculature is not #Innervated like in #PeripheralTissue. #PrecapillarySphincters and/or #FirstOrderCapillaries are central to #NeurovascularCoupling, which may be enhanced by perpendicular alignment of #NeuronalProcesses (12/15)
#neuronalprocesses #neurovascularcoupling #firstordercapillaries #precapillarysphincters #peripheraltissue #innervated #microvasculature #brain
Søren Grubb · @Grubb
20 followers · 19 posts · Server mas.to#MyoendothelialJunctions are 🔗s between #MuralCells and #Endothelia, elsewhere separated by the #BasementMembrane. I show how #Brain #PrecapillarySphincters are 🔥spots for these junctions (yellow dots), like Rhodin showed in 🐇 #PeripheralTissue: https://tinyurl.com/cm8chj56 (7/15)
#peripheraltissue #precapillarysphincters #brain #basementmembrane #endothelia #muralcells #myoendothelialjunctions
Søren Grubb · @Grubb
20 followers · 15 posts · Server mas.to
‼️Importantly, #PrecapillarySphincters exist where a #Capillary branches from a much larger #Arteriole (≈upper cortical layers) but not when there is a more gradual transition (≈lower cortical layers). (3/15)
#arteriole #capillary #precapillarysphincters
Søren Grubb · @Grubb
20 followers · 27 posts · Server mas.to🔥🔥🔥Exciting news! I just published a preprint on the #Ultrastructure of #PrecapillarySphincters and the #NeurovascularUnit. This study is based on the https://www.microns-explorer.org/ dataset by @AllenInstitute. Check 🧵 for more details, including movies of the findings. (1/15)
#neurovascularunit #precapillarysphincters #ultrastructure