Intriguing insight into the crosstalk between matrix stiffness and metabolism.

Teodora Piskova – PhD student in the lab of Jacopo Di Russo #ME3TGradSchool - highlights work from Stephanie Torrino, Thomas Bertero & team. #preprint

“…this work improves our fundamental understanding of the regulation of condensate formation.”

#preLight 👉 https://prelights.biologists.com/highlights/mechano-dependent-sorbitol-accumulation-supports-biomolecular-condensate/

#biochemistry #mechanobiology #metabolism #cancer

Presenting a model for proteasome condensate formation in which shuttle factors play a critical role. ↔ 💧

Kenrick Waite and team #KUMedCenter show that shuttling factors Rad23 and Dsk2 contribute to the localization of proteasomes in condensates - a process that Ddi1 counteracts. #preprint

#preLight by Aniruddha Das 👉 https://prelights.biologists.com/highlights/proteasome-condensate-formation-is-driven-by-multivalent-interactions-with-shuttle-factors-and-k48-linked-ubiquitin-chains/

#proteasome #yeast #condensate

Discovering the dynamic world of the EGFR-MAPK phosphoproteome. 🌐🔎

Feng, Sanford and colleagues #EMSLscience developed a multiplexed deep phosphoproteome profiling workflow unveiling 4500 protein sites exhibiting increased phosphorylation upon EGF stimulation.

Another great #preLight by Benjamin Maier 👉 https://prelights.biologists.com/highlights/a-phosphoproteomics-data-resource-for-systems-level-modeling-of-kinase-signaling-networks-v2/

#preprint # modelling #phosphoproteomics #signalling #bioinformatics #SystemsBiology

I highlighted the new #preprint from Xinnian Dong's lab for @preLights
My #prelights article:

"30-years of searching for the link between local infection and systemic acquired resistance: It’s been ROS all along!"

https://prelights.biologists.com/highlights/h2o2-sulfenylates-che-linking-local-infection-to-establishment-of-systemic-acquired-resistance/

#PlantImmunity #PlantBiology #SystemicAcquiredResistance #prelight #PlantSAR #PlantScience

Weak supervision - Strong results! 💪

Smith and team introduce Perturbational Metric Learning (PeML) to extract biological relationships from noisy high-throughput perturbational datasets.

Team effort from preLighters Benjamin Dominik Maier & Anna Foix Romero – read their preLight! 👀

#preLight 👉 https://prelights.biologists.com/highlights/similarity-metric-learning-on-perturbational-datasets-improves-functional-identification-of-perturbations/

#bioinformatics #SystemsBiology #clustering #correlations #gsea #MachineLearning

Artificial Intelligence can map the landscape of (biomedical) research – and spots gender bias too.

Two recent #preprints from 1) Rita González-Márquez & team 2) Jeroen Verharen describe the use of AI-based tools to explore dynamics within biomedical research & publishing.

preLight by Reinier Prosee – take a look! 👀

#preLight 👉 https://prelights.biologists.com/highlights/the-landscape-of-biomedical-research-chatgpt-identifies-gender-disparities-in-scientific-peer-review-v3/

#AI #publishing #trends #inequality #PeerReview #gender

Move over IgG: WTA-specific IgM is unexpectedly good at targeting Staphylococcus aureus. 🦠

Insightful and entertaining preLight prepared by Lucy Bowden #BYU covering work from the #vanSorgeLab that could inspire new antibody-based therapies & vaccines. #preprint

#preLight 👉 https://prelights.biologists.com/highlights/glycan-specific-igm-is-critical-for-human-immunity-to-staphylococcus-aureus-v2/

#antibodies #staphylococcus #microbiology #immunology #therapy #vaccines

Small but mighty: Sneider and colleagues demonstrate the impact of tissue stiffness on extracellular vesicle-mediated metastasis in breast cancer. #WirtzLab #preprint

Great team effort from preLighters Jade Chan & Yohalie Kalukula – check it out! 👀

#preLight 👉 https://prelights.biologists.com/highlights/small-extracellular-vesicles-promote-stiffness-mediated-metastasis/

#ECM #EVs #metastasis #Cancer

Steer clear of steatosis – VEGFA lipid nanoparticles (LNPs) drive BEC-hepatocyte conversion, an alternative pathway for liver regeneration. #Gouon-EvansLab

Wonderful preLight written by Sakurako Kobayashi and Ryan Brown. They will coordinate more #preprint highlights from the Organogenesis and Cancer Program #PeterMacCC 💡📝

#preLight 👉 https://prelights.biologists.com/highlights/vegfa-mrna-lnp-promotes-biliary-epithelial-cell-to-hepatocyte-conversion-in-acute-and-chronic-liver-diseases-and-reverses-steatosis-and-fibrosis/

#liver, #regeneration, #mice, #zebrafish

A novel form of neuronal plasticity - when a neuron is injured, their healthy neighbour takes up the slack. 🗑️

First preLight from Matthew Davies (@sebastianrumpf) covering work from the #CarrilloLab

#preLight 👉 https://prelights.biologists.com/highlights/glial-draper-signaling-triggers-cross-neuron-plasticity-in-bystander-neurons-after-neuronal-cell-death/

#neuroscience #plasticity #CellDeath #neurodegeneration

How do morphogen signals instruct stem cells to acquire a specific neuronal identity? A #preprint by Neal Amin, Kevin Kelley and team provides us with a roadmap. 🧫 🛣️ 🧠

Great new #preLight from Monica Tambalo which includes a response from the authors...👀

#preLight 👉 https://prelights.biologists.com/highlights/generating-human-neural-diversity-with-a-multiplexed-morphogen-screen-in-organoids/

#morphogens #organoids #StemCells #neuroscience

Ever tried untangling a plate of pasta? 🍝

This #preprint tries to make sense of the spaghetti-like connections of narrowly and broadly tuned olfactory glomeruli in the Drosophila brain.

New post from Timothy W. Schwanitz #Princeton covering work from the #RybakLab

#preLight 👉 https://prelights.biologists.com/highlights/the-unique-synaptic-circuitry-of-specialized-olfactory-glomeruli-in-drosophila-melanogaster/

#neuroscience #microscopy #Drosophila

Reduced power supply without cardiolipin. 🏭

Mechanisms behind a mitochondrial myopathy mutation in the ADP/ATP carrier revealed by a collaborative study from the #ClaypoolLab. #preprint

Read this new preLight from Barbora Knotkova #UniHeidelberg. 👀

#preLight 👉 https://prelights.biologists.com/highlights/conserved-cardiolipin-mitochondrial-adp-atp-carrier-interactions-assume-distinct-structural-and-functional-roles-that-are-clinically-relevant-2/

#mitochondria #LipidProteinInteractions

When mice receive unreliable information from their ears, how do they use their eyes? 🐭

Schenberg & team show that visual reflexes are altered and can supplement info during vestibular stimulation. #preprint

Great new post from Samantha Davis! 👀

#preLight 👉https://prelights.biologists.com/highlights/subchronic-alteration-of-vestibular-hair-cells-in-mice-implications-for-multisensory-gaze-stabilization/

#neuroscience #balance #plasticity

Powerhouse failure...heartbreaking. 💔

Mitochondrial citrate carrier is required for mitochondrial maturation and cardiac development.

Collaborative preLight from Chee Kiang Ewe & Preethi Krishnaraj covering work from the #FaundezLab & #KwongLab.

Read more ⬇️

#preLight 👉 https://prelights.biologists.com/highlights/mitochondrial-citrate-carrier-slc25a1-is-a-dosage-dependent-regulator-of-metabolic-reprogramming-and-morphogenesis-in-the-developing-heart/

#development #heart #metabolism

Sugar-coated food choices: how sucrose changes feeding behaviour through AgRP neuron’ modulation. 🍭🍬🧠

First solo preLight from Cláudia Gil #Metabolcenter who highlights a #preprint from the #BeutlerLab!

Take a look! 👀 ⬇️

#preLight 👉 https://prelights.biologists.com/highlights/sucrose-overconsumption-impairs-feeding-circuit-dynamics-and-promotes-palatable-food-intake/

What doesn’t kill you makes you younger: damage-induced tissue regeneration resets the clock for elderly flatworms. 👩‍🎤🎵

Really entertaining preLight prepared by Sophia Friesen covering work from the #GuoLonghua Lab #UMich. #preprint

#development #physiology #ageing

#preLight 👉 https://prelights.biologists.com/highlights/regeneration-leads-to-global-tissue-rejuvenation-in-aging-sexual-planarians/

A domesticated #transposase required for healthy #neurodevelopment - possibly through developmental #apoptosis and synaptic #plasticity.

First preLight from Amanda Ivanoff #BuffaloState who covers beautiful work from the #KentsisResearch Lab #MSKCancerCenter. #preprint

Take a look! 👀

#preLight 👉 https://prelights.biologists.com/highlights/a-transposase-derived-gene-required-for-human-brain-development/

Discovering the hidden connections between neurons and immune cells in pain perception.

First preLight post from Patrick Penndorf #mpi_ie #FEBSnet covering a #preprint from Aakanksha Jain and team. Includes a response from the authors...👀

#preLight 👉 https://prelights.biologists.com/highlights/nociceptor-neuroimmune-interactomes-reveal-cell-type-and-injury-specific-inflammatory-pain-pathways/

#Neuroimmunology

These cells are made for walking, up a friction-gradient they move, one of these days these cells are gonna crawl away from you. 🎵

#preLightsAmbassador Girish Kale covers a recent #preprint from Adam Shellard and team #mayor_lab.

#preLight: https://prelights.biologists.com/highlights/frictiotaxis-underlies-adhesion-independent-durotaxis/