The PLK1 kinase mandates DNA polymerase theta to safeguard the #genome during #mitosis.

#preLighter Pierre Caron covers a #preprint by Camille Gelot #institut_curie and team that redefines the physiological function of #TMEJ.

#DNArepair #GenomeStability
https://prelights.biologists.com/highlights/pol%ce%b8-is-phosphorylated-by-polo-like-kinase-1-plk1-to-enable-repair-of-dna-double-strand-breaks-in-mitosis/

Missed the 9th International Symposium on the Biology of Vertebrate Sex Determination last week? #VSDHawaii2023

#preLighter Martin Estermann has put together a #preList containing #preprints that were discussed and presented there.

📜 preList: https://prelights.biologists.com/prelists/9th-international-symposium-on-the-biology-of-vertebrate-sex-determination/

Helping funders & institutions as they consider #OpenScience implementation.

Kristen Ratan and colleagues discuss their approach at #ASAP_Research to incorporate open science policies and advance science through reuse and collaboration. #preprint

Great new #preLight from Kanika Khanna!

👉 https://prelights.biologists.com/highlights/from-policy-to-practice-tracking-an-open-science-funding-initiative/

#preLighter #ASAPbio_Fellow

Roses are red, violets are blue, when the disk proper grows, hippo stretches peripodial epithelium too. 🌹

A new post from Girish Kale covering a #preprint led by another #preLighter: Sophia Friesen who works in the #HariharanLab

Check it out! 👉 https://prelights.biologists.com/highlights/coordinated-growth-of-linked-epithelia-is-mediated-by-the-hippo-pathway/

Two new posts on preLights today! 👀

The first has been written by our new #preLighter Yueh Cho (postdoc at #IPMBSinica & #AcadSinica) who covers a #preprint from Tina Schreier and colleagues which shows that light and photosynthesis trigger plasmodesmal formation in C4 dicotyledons 🌱

📜 https://prelights.biologists.com/highlights/plasmodesmal-connectivity-in-c4-gynandropsis-gynandra-is-induced-by-light-and-dependent-on-photosynthesis/

#plants #grasses #dicotyledons #plasmodesmata

An inducible tagging strategy to label proteins enables nanometer-scale localisation of molecules in human cells. #cryo-ET #FluorescenceMicroscopy. 🔬

📜 https://prelights.biologists.com/highlights/genetically-encoded-multimeric-tags-for-intracellular-protein-localisation-in-cryo-em/

#preLighter Martyna Kosno-Vega covers an exciting #preprint from the #MahamidLab #EMBLHeidelberg.

#biochemistry #bioengineering #imaging #biophysics

Happy New Year! 🎆 Two preLights to kick off 2023.

2nd: urban-adapted mosquitoes may spread malaria to new regions as the Earth warms 🦟🌎 - an important (and alarming) #preprint from Sadie J. Ryan, Catherine A. Lippi and colleagues.

By #preLighter Sophia Friesen #HariharanLab #Berkeley

📜 https://prelights.biologists.com/highlights/mapping-current-and-future-thermal-limits-to-suitability-for-malaria-transmission-by-the-invasive-mosquito-anopheles-stephensi/

Happy New Year! 🎆 Two new #preLights to kick off #2023.

1st: It’s all clicking together - Keqing Nian, Yifang Liu, Laura Brigandi & Sara H. Rouhanifard develop a DNA oligomer-conjugated ligand for copper-catalysed azide-alkyne cycloadditions.

By #preLighter @zhanghe_goh #EPSRC #CDT #Cambridge

📜 https://prelights.biologists.com/highlights/dna-enhanced-cuaac-ligand-enables-live-cell-detection-of-intracellular-biomolecules/

RT @preLights
#Day7: Seven Swans a-swimming 🎵

#preLighter @SamanthaNDavis_ highlighted a #preprint from @SharkMagneto, @findingdovi, @nilssonsro, Allison Saettele, @GoldenNeuron & @Oly_Binewski on how the lateral line system helps fish efficiently swim into flow 🏊

https://prelights.biologists.com/highlights/lateral-line-ablation-by-ototoxic-compounds-results-in-distinct-rheotaxis-profiles-in-larval-zebrafish/

Check out the latest #post @preLights? 📜👀

https://prelights.biologists.com/highlights/expansion-microscopy-at-one-nanometer-resolution/

#preLighter Nadja Hümpfer covers a #preprint which describes the combination of #SRRF analysis with 10-fold expansion microscopy #ExM. 🔬 Their approach allows a final resolution of 1 nm; a #resolution at which the shape of individual proteins becomes apparent when labelled with a pan-protein staining.

This preLight also includes comments from #authors Ali H. Shaib & Silvio O. Rizzoli 📝

#ONE_Microscopy #immunoglobulin

Navigating a tense situation: the plasma #membrane and actin #cortex form an integrated system for rapid long-range #tension #propagation.

📜 https://prelights.biologists.com/highlights/actin-driven-protrusions-generate-rapid-long-range-membrane-tension-propagation-in-cells/

#preLighter Nicolaes Hyun-Kee Min covers a beautiful #preprint from @HenryDeBelly and team (Weiner, Turlier, and Bustamante labs) which provides a simple and widely applicable #model of how tension propagates. One that not only considers membrane rigidity/fluidity, but the underlying actin cortex as well.