'The transcriptomic signature of human acute kidney injury was enriched with genes in pathways involved in cell adhesion and epithelial-to-mesenchymal transition (e.g., CDH6, ITGB6, CDKN1A).'
#Preprint

https://www.biorxiv.org/content/10.1101/2023.09.11.557054v1

'Using mammalian cells in culture, we discovered that they adapt to chronic mild stresses of up to two weeks, notably proteotoxic stresses such as heat, by increasing their size and translation, thereby scaling the amount of total protein.'

#Preprint #CellBiology

https://www.biorxiv.org/content/10.1101/2023.01.25.525547v3

A new #preprint #OpenScience #PeerReview by @PCI_Ecology: Yuval R. Zelnik, Matthieu Barbier, David W. Shanafelt, Michel Loreau, Rachel M. Germain (2023) Linking intrinsic scales of ecological processes to characteristic scales of biodiversity and functioning patterns. bioRxiv, ver. 2 peer-reviewed and recommended by Peer Community in Ecology. https://doi.org/10.1101/2021.10.11.463913 🔽

The last couple of weeks have seen us improving on some of the recently shipped functionality on Sciety. Learn more about it in our latest product update

https://blog.sciety.org/weeknotes/sciety-product-news-26-2023/

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https://sciety.us10.list-manage.com/subscribe?u=cdd934bce0d72af033c181267&id=945c088a28

#preprint #OpenScience #ScienceMastodon

Is the lack of published non-significant results the fault of reviewers and editors refusing to publish them, or do researchers refuse to even write such results up? Interesting article using pre print servers to suggest the latter is the explanation… #preprint #scientificpublishing #Science https://www.newthingsunderthesun.com/pub/swbmzhyg/release/8?utm_medium=email&utm_source=substack

#Preprint met een overzicht van hoe #Covid de kans op hart- en vaatziekten verhoogt.

Deze resultaten stemmen overeen met de waarschuwing van Lauterbach.

#ABReview

https://www.medrxiv.org/content/10.1101/2023.09.05.23295067v1

Intriguing insight into the crosstalk between matrix stiffness and metabolism.

Teodora Piskova – PhD student in the lab of Jacopo Di Russo #ME3TGradSchool - highlights work from Stephanie Torrino, Thomas Bertero & team. #preprint

“…this work improves our fundamental understanding of the regulation of condensate formation.”

#preLight 👉 https://prelights.biologists.com/highlights/mechano-dependent-sorbitol-accumulation-supports-biomolecular-condensate/

#biochemistry #mechanobiology #metabolism #cancer

Have you ever wondered what is the availability of cloud-, snow-, and shade-free #Landsat and #Sentinel2 🛰️observations over Europe? Ponder no more: https://katarzynaelewinska.users.earthengine.app/view/europedataval; #preprint: https://preprints.org/manuscript/202308.2174
P.S. the World-wide analysis is coming shortly

📣#preprint alert! Check out Tao’s latest work on streak #waviness and the self-sustained process in wall-bounded #transition to #turbulence
https://arxiv.org/abs/2308.16792 @PMMH_lab @ESPCI_Paris @psl_univ @INSIS_CNRS @ScienceSorbonne @univ_paris_cite

Very interesting. Sequence-function relation is expected to be simpler than often expected, according to the preprint. I'd love to see comments or reviews on this one. #preprint #bioinformatics #protein

The simplicity of protein sequence-function relationships | bioRxiv
https://www.biorxiv.org/content/10.1101/2023.09.02.556057v1

My first PhD chapter is out as a #preprint on biorxiv! We had a look at what funky incubation periods in #rabies could be doing to it’s genetic divergence https://www.biorxiv.org/content/10.1101/2023.09.04.556169v1

Presenting a model for proteasome condensate formation in which shuttle factors play a critical role. ↔ 💧

Kenrick Waite and team #KUMedCenter show that shuttling factors Rad23 and Dsk2 contribute to the localization of proteasomes in condensates - a process that Ddi1 counteracts. #preprint

#preLight by Aniruddha Das 👉 https://prelights.biologists.com/highlights/proteasome-condensate-formation-is-driven-by-multivalent-interactions-with-shuttle-factors-and-k48-linked-ubiquitin-chains/

#proteasome #yeast #condensate

A new #preprint #OpenScience #PeerReview by @PCI_AnimSci: Gebhardt-Henrich et al. (2023) Validation of a Radio frequency identification system for tracking location of laying hens in a quasi-commercial aviary system.https://doi.org/10.1101/2023.02.16.528820 recommended by Anna Olsson for @PCI_AnimSci based on published reviews by Mona Giersberg and Arjen van Putten #OpenScience https://doi.org/10.24072/pci.animsci.100193

A new #preprint #OpenScience #PeerReview by @PCI_AnimSci: Gebhardt-Henrich et al. (2023) Validation of a Radio frequency identification system for tracking location of laying hens in a quasi-commercial aviary system.https://doi.org/10.1101/2023.02.16.528820 recommended by Anna Olsson for @PCI_AnimSci based on published reviews by Mona Giersberg and Arjen van Putten #OpenScience https://doi.org/10.24072/pci.animsci.100193

"Here we find, in a clinical cohort of at-risk infants, broad spectrum antibiotic treatment, including cephalosporins, increased the risk of late-onset sepsis in neonates in comparison to penicillin base treatments"
#Preprint #Immunology #MucosalImmunology

https://www.medrxiv.org/content/10.1101/2023.09.04.23295031v1

RecRec: Algorithmic Recourse for Recommender Systems https://arxiv.org/pdf/2308.14916.pdf #preprint ML models underlying #RecSys are often opaque, making it difficult for users, content providers, and developers to understand why certain recommendations are made.

To address this problem, this paper proposes a recourse framework for recommender systems. A recourse is a set of actions that, if executed, would modify the recommendations (or ranking) of an item in the desired manner.

'Here, we reveal that gut commensal bacteria can translocate directly to the brain when mice are fed an altered diet that causes dysbiosis and intestinal permeability, and that this also occurs without diet alteration in distinct murine models of neurological disease. The bacteria were not found in other systemic sites or the blood, but were detected in the vagus nerve.'
#Preprint

https://www.biorxiv.org/content/10.1101/2023.08.30.555630v1

'However, the contribution of stromal cells of the hematopoietic niches in the control of HSPC asymmetric divisions remains unknown. Using polyacrylamide microwells as minimalist niches, we show that heterotypic interaction with osteoblast promotes asymmetric division of human HSPC.'
#Preprint

https://www.biorxiv.org/content/10.1101/2023.08.31.555706v1

New #preprint on @sortee's EcoEvoRxiv, looking at the genetic variance in group size, which is tricky conceptually as it is a trait shared among many individuals. Using an indirect genetic effects framework, I suggest genetic variance should be high and therefore group size highly evolvable: https://doi.org/10.32942/X2S30S

New #preprint about our experiences offering 'reproducibility as a service' for a six month period: https://psyarxiv.com/k8d4u/

We made 10 papers #reproducible from @YorkPsychology covering a wide range of study designs, supported by funding from Research England 1/6