The lysosomal degraders

#PROTAC +derivatives

An update on Research & Commercialization of #MolecularGlue for targeted protein degradation

"LYTACs, ATACs, AbTACs, KineTACs, PROTABs, AUTACs, ATTECs and AUTOTACs"

Ken Garber Nature Biotech 2022
https://www.nature.com/articles/s41587-022-01594-7

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01243 #PROTAC#FLUORESENCE#probe#ChemicalBiology #medicinalchemistry

#PROTAB proteolysis-targeting antibody
An evolving #PROTAC variant

Use tumor-enriched cell surface #E3Ligase RNF43/ZNRF3 for targeted degradation of transmembrane proteins IGF1R/HER2/PD-L1

Dr. N. Agard & F. de Sousa e Melo labs @Nature 2022 @genentech
https://www.nature.com/articles/s41586-022-05235-6