preLights · @preLights
596 followers · 38 posts · Server biologists.social
Presenting a model for proteasome condensate formation in which shuttle factors play a critical role. ↔ 💧
Kenrick Waite and team #KUMedCenter show that shuttling factors Rad23 and Dsk2 contribute to the localization of proteasomes in condensates - a process that Ddi1 counteracts. #preprint
#preLight by Aniruddha Das 👉 https://prelights.biologists.com/highlights/proteasome-condensate-formation-is-driven-by-multivalent-interactions-with-shuttle-factors-and-k48-linked-ubiquitin-chains/
#kumedcenter #preprint #prelight #proteasome #yeast #condensate
The EMBO Journal · @embojournal
548 followers · 284 posts · Server sciencemastodon.com
Global histone H2B degradation regulates #insulin/#IGF signaling-mediated nutrient stress
The #ubiquitin-#proteasome system regulates #histone #H2B exchange in mammalian cells and in C. elegans during development and starvation.
#insulin #Ubiquitin #proteasome #histone #h2b
The EMBO Journal · @embojournal
452 followers · 204 posts · Server sciencemastodon.com
Chloroplast protein import is controlled not just by the #ubiquitin-#proteasome system, but also by selective #NBR1-mediated selective #autophagy of translocon components in #Arabidopsis upon UV light or heat stress
https://www.embopress.org/doi/10.15252/embj.2022112534
#Ubiquitin #proteasome #nbr1 #autophagy #arabidopsis
preLights · @preLights
520 followers · 112 posts · Server mstdn.science
First #preLight post from Aniruddha Das.
Aniruddha picked a #preprint from the #AOri_lab and team in which proximity labelling is used to identify interactions between the #proteasome and membrane-associated proteins or transcription factors.
#prelight #preprint #aori_lab #proteasome
CellBioNews · @cellbionews
25 followers · 537 posts · Server scientificnetwork.deResearchers reveal #endoplasmic reticulum–associated #protein degradation and control of grain size in #rice.
#agriculture #ubiquitin #proteasome
https://phys.org/news/2023-02-reveal-endoplasmic-reticulumassociated-protein-degradation.html
#endoplasmic #protein #rice #agriculture #Ubiquitin #proteasome
The EMBO Journal · @embojournal
403 followers · 84 posts · Server sciencemastodon.com
In EMBO Journal issue 3:
Host #mucins negotiate peace with #toxigenic #Vibrio
Cytosolic #stressgranules relieve nuclear #ubiquitin-#proteasome system
#Smoothened #cholesterylation and ER exit links in #Hedgehog signaling
Developmental #cellfate decision control by #chromatin reader #TRIM33
Cover by Kimon Lemonides, Helen Walden et al
#mucins #toxigenic #vibrio #StressGranules #Ubiquitin #proteasome #smoothened #cholesterylation #hedgehog #cellfate #chromatin #trim33
The EMBO Journal · @embojournal
371 followers · 64 posts · Server sciencemastodon.com
What happens to the #ubiquitin-#proteasome system in cells that cannot form #stressgranules?
Nico Dantuma & coworkers at Karolinska Institute find surprising #nucleolar relocalization of DRiP #peptides, compromising #proteostasis in the nucleus
https://www.embopress.org/doi/10.15252/embj.2022111802
#Ubiquitin #proteasome #StressGranules #nucleolar #peptides #proteostasis
Thijs Bressers · @Tbressers
21 followers · 57 posts · Server qoto.org
RT @Barandunlab
Very excited to share our latest published #cryoEM work on the #microsporidian #proteasome with all its proteolytic sites inhibited simultaneously by a PI31-like peptide!! Fantastic job from Nathan, Kai, Rahel, and Dennis, and collaboration with Charlie (@CT_CAES)!
#cryoEM #microsporidian #proteasome
CRAIG M CREWS · @crews
350 followers · 142 posts · Server mstdn.scienceI'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup
#hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #ChemicalBiology #biochem #cellbiology #biotech #biopharma #ligase #Ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup