Exciting to see a new protein generative diffusion model in preprint! We look forward to trying the Genie model from Mohammed AlQuraishi https://www.aqlab.io/. The preprint is here and we hear that the code will be released soon. https://arxiv.org/abs/2301.12485 #ai #proteinengineering #proteinai #drugdiscovery

Exciting to see a new protein generative diffusion model in preprint! We look forward to trying the Genie model from Mohammed AlQuraishi https://www.aqlab.io/ https://arxiv.org/abs/2301.12485 #ai #proteinengineering #proteinai #drugdiscovery

Great summary of recent protein diffusion #ai models from the Baker lab and Namrata Anand (Stanford) in the NYT! We are excited for the diffusion models to start making an impact on de novo design for drug discovery.#proteinai #drugdiscovery (unpaywalled link) https://www.nytimes.com/2023/01/09/science/artificial-intelligence-proteins.html?unlocked_article_code=s_t7RtEDLdq2lgWJVCDjST--kz1rNphFpK5JwwsY9MvrUcwEsT8n6283SCFhPegB8WtXsL-cg2Tcwye7A1MJ-rcpkAT4uNId6quZdVYF51cmHT7aRBQZkstB3i8oNwykLu3Ye-jM2RFUEWz4URM4ZvLyO8mfV6cQVQ3_7eyVO9dcpSQeJInuj93Z7Jm0iMsIF1SnKQeVmb1S5YRsWYSy2wK-9I_TxWUf7H3vAZo0NRXcRkozp6IjLgVk8MsZusv_0Q0556-zMv219q4wy-3YDrj3sPTuuuF652OxSmkfcm3w7dFBknvTRhMWKZTDoCWAdK5W73FYd0RIDlzYwsOyVqqG9hBBZO6xkQ&smid=share-url

@sokrypton Congrats all! Very exciting to push this combination of language models and structure models. AF2 and OF have been frustrating for design, not too surprisingly, but this all makes a ton of sense as a next step! #drugdiscovery #ai #proteinai #proteindesign

7/
Cyrus also recently co-founded the OpenFold consortium for biological AI with Prescient/Genentech, Arzeda, Outpace and help from AWS, to help provide fully open sourced platform models in molecular modeling (openfold.io).

#drugdiscovery #ai #proteinai #proteindesign #structbio

Learn more here:
Cyrusbio.com

This paper is impressive because it introduces the model and more importantly demonstrates working designs including a very strong (strongest yet?) de novo binding protein. Also unusually high success rate. Protein design already often works, this is a significant improvement for re novo. Critical to show these data! Lots of impressive past designs failed in the lab #biotech #proteinai #ai

This paper is impressive because it introduces the model and more importantly demonstrates working designs including a very strong (strongest yet?) de novo binding protein. Also unusually high success rate. Protein design already often works, this is a significant improvement for re novo. Critical to show these data! Lots of impressive past designs failed in the lab #biotech #proteinai #ai

Quoting Mohammed AlQuraishi (Columbia U) from Twitter: OpenFold preprint is out! https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1 Much richer story than expctd 1) AF2 shockingly robust to data elision; train on 1k chains→get AF1 acc; train on helices or sheets→do ok on other 2) it learns 1D→2D→3D proteins. Tweetorial in Gustaf Ahdritz's twitter today #biotech #ai #proteinai #drugdiscovery

Our company @cyrusbiotech is not here yet, but we are excited to announce our Free and Open Source consortium in biomolecular #ai is growing #proteinai https://www.businesswire.com/news/home/20221122005163/en/%C2%A0OpenFold-AI-Research-Consortium-Welcomes-4-New-Members-Bayer-Dassault-CHARM-Therapeutics-and-BaseCamp-Research

@KevinKaichuang maybe there can be something here like #proteinai or similar? Search ability here relies more on hashtags