Using X-ray crystallography at the Advanced Light Source (ALS), research scientist Banumathi Sankaran at the Berkeley Center for Structural Biology (BCSB) has helped confirm the successful design of proteins that toggle between two different shapes in response to biological triggers.
Berkeley Lab #ProteinDesign #MachineLearning #StructuralBiology #Science #RoseTTAFold #ProteinMPNN #AlphaFold2
#proteindesign #MachineLearning #structuralbiology #science #RoseTTAFold #proteinmpnn #AlphaFold2
Referenced link: https://phys.org/news/2023-04-board-games-protein.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-04-board-games-protein.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1649110707890266113#m
#Reinforcementlearning: From board games to #proteindesign @uwmedicine @sciencemagazine https://phys.org/news/2023-04-board-games-protein.html
#reinforcementlearning #proteindesign
Also, #ICYMI here's my #ProteinDesign #preprint with Flo: https://www.biorxiv.org/content/10.1101/2023.01.27.525968v1
#icymi #proteindesign #preprint
The era of #proteindesign really is coming along nicely.
#proteinengineering
#enzymeengineering
https://www.nature.com/articles/s41586-023-05696-3
Twitter thread from Institute for Protein Design
https://twitter.com/UWproteindesign/status/1628438074404507648?t=goy2swbeDBU7nux-nmG9jg&s=19
#proteindesign #proteinengineering #enzymeengineering
26-JAN-2023
AI technology generates original #proteins from scratch
#proteins #proteindesign #nanoworld #structuralbiology
Large language models generate functional protein sequences across diverse families.
Super interesting #ProteinDesign work.
#StructuralBiology #Crystallography
@strucbio
https://www.nature.com/articles/s41587-022-01618-2
#proteindesign #structuralbiology #crystallography
Design of amyloidogenic peptide traps
#proteindesign #biotech #preprint #biorxiv #alzheimer #neurodegeneration
#neurodegeneration #alzheimer #biorxiv #preprint #biotech #proteindesign
@sokrypton Congrats all! Very exciting to push this combination of language models and structure models. AF2 and OF have been frustrating for design, not too surprisingly, but this all makes a ton of sense as a next step! #drugdiscovery #ai #proteinai #proteindesign
#drugdiscovery #ai #proteinai #proteindesign
7/
Cyrus also recently co-founded the OpenFold consortium for biological AI with Prescient/Genentech, Arzeda, Outpace and help from AWS, to help provide fully open sourced platform models in molecular modeling (openfold.io).
#drugdiscovery #ai #proteinai #proteindesign #structbio
Learn more here:
Cyrusbio.com
#ai #drugdiscovery #proteinai #proteindesign #structbio
This feels very futuristic.
A de novo protein catalyzes the synthesis of semiconductor quantum dots
https://www.pnas.org/doi/abs/10.1073/pnas.2204050119?af=R
#structuralbiology #proteindesign #Science
David Bakers talk
"The coming of age of de novo protein design" at the NIH from Dec. 14th
#proteindesign #enzymeengineering
De novo protein design by inversion of the AlphaFold structure prediction network
#alphafold #proteindesign #preprint
Dec 13th at 12pm EST
Join #SBGrid to learn about Proteus, a general purpose tool for protein design, used to redesign entire proteins or functional sites, such as ligand-binding pockets.
Prof. Thomas Simonson will present, from the BIOS Research Group, BIOcomputing and Structure, École Polytechnique and the Centre national de la recherche scientifique
Free & open to the scientific community. Register at: https://sbgrid.org/webinars/
#structuralbiology #proteins #proteindesign #proteinengineering
#sbgrid #structuralbiology #proteins #proteindesign #proteinengineering
@Klausenhauser great work from @uwproteindesign who aren’t on #fediverse yet #proteindesign
I finally have the time to write an introduction:
I am a #structuralbiology #scientist, currently working in the #biomed industry. I have a long-standing interest in the study the correlation between the 3D structure and dynamics of proteins and their regulation mechanisms. thought my research I had used #NMR, #xrayscattaring, #SPR, FTIR, #moleculardynamics, #modelling, #Docking, #proteindesign and more.
When I have time, I enjoy to #run, specifically do #trailrun with my kids.
#trailrun #run #proteindesign #docking #modelling #moleculardynamics #spr #xrayscattaring #nmr #biomed #scientist #structuralbiology
‘The dark matter is just sitting there’: What’s standing in the way of AI for life sciences - Life sciences panelists at Madrona Venture Group’s Intelligent Application Summit... - https://www.geekwire.com/2022/the-dark-matter-is-just-sitting-there-whats-standing-in-the-way-of-ai-for-life-sciences/ #health/lifesciences #cyrusbiotechnology #proteindesign #rosettafold #lucasnivon #alphafold #ai
#ai #alphafold #lucasnivon #rosettafold #proteindesign #cyrusbiotechnology #health