MCDuncanLab · @MCDuncanLab
250 followers · 1613 posts · Server mstdn.socialClearly, there is still much to learn about this corner of the dark genome defined by HEATR5 proteins and their co-factors.
#Biorxiv #Preprint #MembraneTraffic #DarkGenome #DarkProteome #RareDisease #AlphaFold #AlphaFold2 #ProteinPrediction #Golgi #Clathrin #CellBiology #biochemistry #Bioscience
#bioscience #biochemistry #CellBiology #clathrin #golgi #proteinprediction #alphafold2 #alphafold #raredisease #darkproteome #darkgenome #membranetraffic #preprint #biorxiv
MCDuncanLab · @MCDuncanLab
250 followers · 1613 posts · Server mstdn.socialBiochemical analysis revealed that Lft1 and Laa2 bind to Laa1 via the same interface. Following a suggestion by a colleague to try Alphafold2, we found that the two likely bind via a common mechanism, although the Lft1 interface is a little larger—something confirmed by our biochemical results.
#proteinprediction #alphafold2 #alphafold