Dave Briggs :protein: · @xtaldave
1274 followers · 1096 posts · Server xtaldave.net
TMEM2: a hyaluronidase without* hyaluronidase activity, and a gorgeous structure.
Check out that beta-helix though :blobcataww:
https://wellcomeopenresearch.org/articles/8-76
#crystallography #StructuralBiology #Glycotime #Proteoglycans @strucbio
#crystallography #structuralbiology #Glycotime #proteoglycans
Dave Briggs :protein: · @xtaldave
1185 followers · 3701 posts · Server xtaldave.netUsing heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis
https://www.pnas.org/doi/abs/10.1073/pnas.2209528120?af=R
Looks Interesting. Will have to dig into this and find out why an 18-mer...
#Glycotime #proteoglycans #Science #research
Dave Briggs :protein: · @xtaldave
1181 followers · 3642 posts · Server xtaldave.net
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors.
Nice work led by Doug Dyer's group in Manchester - CXCL4 doesn't appear to have a protein receptor, rather it binds GAG chains on a wide range of cell surface proteoglycans.
#Glycotime #Proteoglycans #xp
#Science #Research
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01831-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722018319%3Fshowall%3Dtrue#%20
#Glycotime #proteoglycans #xp #Science #research
Alejandro Adam · @aleadam
12 followers · 33 posts · Server universeodon.comTissue, Matrix and Pathobiology 2023, a joint meeting this October from ASIP, HCS and ASMB
Topics include #liver, #lung and #kidney #fibrosis, #cancer #metastasis, #inflammation, #cardiovascular #disease, #development, #neuropathology, #proteoglycans, #cell #junctions, #sphingolipids, #tissue #clearing, and more!
#liver #lung #kidney #fibrosis #cancer #metastasis #inflammation #cardiovascular #disease #development #neuropathology #proteoglycans #cell #junctions #sphingolipids #tissue #clearing