I would like to light a candle for Carl Sassenrath's abandoned #REBOL.
Spent a fair bit of time doing projects in REBOL for work back in the day, and if it had only been open sourced from the start I believe the timing would have propelled it to the forefront of native networked GUI apps.
#RedLang has taken up the mantle, but if IIRC it's still stuck in a rewrite to shed the ancient 32-bit prerequisite tooling.