How & why are #circadian rhythms maintained in red blood cells? Novel #haemoglobin #oxidation assay reveals it to be linked to body temperature regulation
A #RefereedPreprint c/o @ReviewCommons by John O‘Neill, Michael Hastings and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2023114164

New microscopy assay by Sue Biggins and collaborators #fredhutch enables direct observation of coordinated de novo assembly of native #CENPA #nucleosomes driven by several protein cofactors and the AT run content of #centromeric DNA
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023114534

Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway
Jean-Léon Maître and coworkers
#RefereedPreprint c/o @ReviewCommons

Proximity of chromosomes to the cell cortex induces excessive contractions of the actomyosin cortex and cell fragmentation in the early mouse embryo

https://www.embopress.org/doi/full/10.15252/embj.2023114415

How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells

#RefereedPreprint c/o @ReviewCommons

https://www.embopress.org/doi/10.15252/embj.2022112684

The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion
Petr Chlanda and colleagues
Previously a #RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023113578

ATP-induced conformational change of #axonemal outer #dynein arms revealed by cryo-electron #tomography

#RefereedPreprint via @ReviewCommons by Takashi Ishikawa et al

https://www.embopress.org/doi/10.15252/embj.2022112466

RT @embojournal
Transcription pre-initiation complex formation & composition is not as uniform as we thought:
@stark_lab @IMPvienna finds distinct PICs acting at housekeeping vs. developmentally-regulated promoters in Drosophila cells
#RefereedPreprint via @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023113519

RT @embojournal
Transcription pre-initiation complex formation & composition is not as uniform as we thought:
@stark_lab @IMPvienna finds distinct PICs acting at housekeeping vs. developmentally-regulated promoters in Drosophila cells
#RefereedPreprint via @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023113519

#Transcription #preinitiation complex formation and composition is not as uniform as we thought:

@stark_lab @IMPvienna finds distinct PICs acting at housekeeping genes vs. #developmentally-regulated #promoters in #Drosophila cells

Another former #RefereedPreprint c/o @ReviewCommons

https://www.embopress.org/doi/10.15252/embj.2023113519

How is #biomass production controlled during cell growth and the cell cycle?

New assay by Clovis Basier & Paul Nurse @thecrick using unperturbed exponentially growing populations shows how #cellcycle and cell size affect global rates of RNA and protein synthesis in #fissionyeast

#RefereedPreprint c/o @ReviewCommons now published in revised form!

https://www.embopress.org/doi/10.15252/embj.2022113333

Regulation of branched versus linear #Arp2/3-generated #actin filaments

#RefereedPreprint via @ReviewCommons by Luyan Cao et al

https://www.embopress.org/doi/10.15252/embj.2022113008

How do select pre-#mRNAs escape 3’ end-processing inhibition by #DNAdamage?
Stephan Vagner and colleagues (Institut Curie) invoke rescue by a #cotranscriptional cleavage that allows subsequent #posttranscriptional #polyadenylation site processing in the nucleoplasm

Now published, previously a #RefereedPreprint via @ReviewCommons

https://www.embopress.org/doi/10.15252/embj.2022112358