Cracking the functional domains of the RADX gene during replication. 🧬

Jessica Chevallier & Pierre Caron together highlight work from the #CortezLab which is now available online, ahead of print #JMolBiol.

Read the preLight! 👉https://prelights.biologists.com/highlights/crispr-dependent-base-editing-screens-identify-separation-of-function-mutants-of-radx-with-altered-rad51-regulatory-activity/

#CRISPR #GenomeStability #Replication #DSBs

Ars Technica: The room-temperature superconductor that wasn’t https://arstechnica.com/?p=1965900 #Tech #arstechnica #IT #Technology #superconductivity #materialsscience #replication #chemistry #Science #LK-99

The room-temperature superconductor that wasn’t - Enlarge / Levitation like this will apparently continue to require extr... - https://arstechnica.com/?p=1965900 #superconductivity #materialsscience #replication #chemistry #science #lk-99

The Book of Geometron html mirrored on Gitlab

https://re-leaf.gitlab.io/releaf-static/book/geometron.html

#Geometron #replication

Blast from over two decades past: #Replication and extension of the association of #Neuroticism with reduced brain volume! (#neurophenotype; partially moderated by behavioral adjustment; featuring old friends on the author list):
https://onlinelibrary.wiley.com/doi/10.1111/jopy.12858

OpenZFS #Data #Replication - Replicating Data Quickly and Safely with #OpenZFS

https://klarasystems.com/webinars/webinar-openzfs-data-replication/

@trashrobot@trashmagic.community #replication of the #chaosAmplifier

@trashrobot@trashmagic.community #asAboveSoBelow from #p5js to #cardboard #replication

TIL that temporal separation is not a strategy for avoidance of transcription-replication conflict.

"Considering all data together, during the S-phase, all three RNA Polymerases are active, indicating that the timely separation of transcription and replication is not a strategy that eukaryotic cells deploy to avoid the occurrence of collisions."

https://doi.org/10.3390%2Flife12010108
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781949/

#DNA #transcription #replication

Were base rate fallacies more or less likely when people were reading in a foreign language?

Not among a couple hundred European Portuguese bilinguals, regardless of whether the emotional salience of the lure was exaggerated.

Master’s thesis: https://hdl.handle.net/1822/86018

#JDM #logic #probability #decisionScience #language #ESL #replication

In this conference paper for #ForumAcousticum #FA2023 we replicate Ahumada's seminal experiment from 1975 on tone-in-noise perception using our own #OpenSource fastACI toolbox (https://github.com/aosses-tue/fastACI), and we analyze the data obtained by an artificial listener from the (also #OpenSource) Auditory Modeling Toolbox on the task. It's very satisfactory to have a network of interconnected toolboxes working together... And of course all analyses can be reproduced easily using the commands listed in the article. You can even run the experiment on yourself to replicate Ahumada's original results! #replication #OpenCode #Auditory #Psychoacoustics
https://hal.science/hal-04186363v1/document

In this conference paper for #ForumAcousticum #FA2023 we replicate Ahumada's seminal experiment from 1975 on tone-in-noise perception using our own #OpenSource fastACI toolbox (https://github.com/aosses-tue/fastACI), and we analyze the data obtained by an artificial listener from the (also #OpenSource) Auditory Modeling Toolbox on the task. It's very satisfactory to have a network of interconnected toolboxes working together... And of course all analyses can be reproduced easily using the commands listed in the article. You can even run the experiment on yourself to replicate Ahumada's original results! #replication #OpenCode
https://hal.science/hal-04186363v1/document

In this conference paper for #ForumAcousticum #FA2023 we replicate Ahumada's seminal experiment from 1975 on tone-in-noise perception using our own #OpenSource fastACI toolbox (https://github.com/aosses-tue/fastACI), and we analyze the data obtained by a model from the (also #OpenSource) Auditory Modeling Toolbox on the task. It's very satisfactory to have a network of interconnected toolboxes working together... And of course all analyses can be reproduced easily using the commands listed in the article. You can even run the experiment on yourself to replicate Ahumada's original results! #replication #OpenCode
https://hal.science/hal-04186363v1/document

https://hal.science/hal-04186363v1/document
In this conference paper for #ForumAcousticum #FA2023 we replicate Ahumada's seminal experiment from 1975 on tone-in-noise perception using our own #OpenSource fastACI toolbox (https://github.com/aosses-tue/fastACI), and we analyze the data obtained by a model from the (also #OpenSource) Auditory Modeling Toolbox on the task. It's very satisfactory to have a network of interconnected toolboxes working together... And of course all analyses can be reproduced easily using the commands listed in the article. You can even run the experiment on yourself to replicate Ahumada's original results! #replication #OpenCode

Are those guys serious? In August 2023 they post a so called "comprehensive guide" how to setup #PostgreSQL #replication on Ubuntu 18.04 with PostgreSQL version 10??? This software is EOL almost one year now.

https://kinsta.com/blog/postgresql-replication/

What is #kinsta anyway? They call it a home for *modern* web apps and sites. I call it a #fail

How can #replication initiator ORC load replicative #helicases in condensed chromatin?
Structural and biochemical work by Franziska Bleichert and colleagues shows how ORCA recruits ORC to certain #histone marks, and also reorganizes local #chromatin structure
https://www.embopress.org/doi/full/10.15252/embj.2023114654

[video] Transactional Replication for Azure SQL Managed Instance by Sasa Popovic: https://youtu.be/dQ6JA2a_A8o

#azuresql #sqlmi #replication

Why is there a ton of complex distributed #filesystem's and a bunch of p2p file sync solutions, and, of course, bunch of automagically sharding and object stores,

But not a single one well-maintained simple solution for one-way live filesystem #replication (that I could find)?

Is it just not what super serious "high availability" #devops people ever need or what.

I just want a live copy of everything I have on a server on another server. Currently using #Syncthing for that but even that feels like way too many failure modes for what is basically #rsync in a loop.

Thinking of building a basic thing that hooks into fanotify and maintains an append-only log of changes and hashes, and plays those back to the replica client over ssh or tls.

Can't help but feel I'm missing something crucial that would make it fail in a major way. Surely it can't be that simple.

''We conclude that despite considerable #genetic variances, all three contemporary swine-origin A(#H3N2) viruses displayed a capacity for robust #replication in the #ferret respiratory tract and were also capable of limited #airborne #transmission.''

#OpenZFS #replication is an incredibly powerful tool in every sysadmins' tool belt. Join us on Wednesday, September 13th as Klara co-founder Allan Jude and ZFS Expert Jim Salter examine how to reliably replicate data using ZFS send and receive.

Sign up: https://klarasystems.com/webinars/webinar-openzfs-data-replication/