We are glad that the editorial team at #TranslationalMedicineOfAging and the peer-reviewers agreed that these were important results to disseminate to the #ReproAging research community.
We also thank @GCRLE1@twitter.com for supporting our work! @USCLeonardDavis@twitter.com 5/5

As noted before, although we are disappointed that these mice cannot be used to effectively model menopausal states, we hope our observations will be useful to the #ReproAging community and avoid unnecessary waste of animals/time/resources by other labs. 4/5

We confirmed that the #KOMP allele should correspond to a null allele (confirmed by Sanger🧬), but it seems that the wild-type allele is compensating in this 🐁 strain, leading to normal Fshr expression, ovarian function and absence of #ReproAging phenotype.
3/5

Previous tweetorial on the preprint below - briefly, we did not observe any indication of accelerated #ReproAging in the #KOMP Fshr allele, contrary to previous work (on a distinct allele), based on breeding, endocrine markers and histology.
2/5 https://twitter.com/BBParis1984/status/1578525667620098049?s=20&t=kkhCl_hXSu3SGPri8ReUmw

We hope that this study will be a useful resource for #ReproAging research and #TE Biology!
We also thank @param_p_singh@twitter.com, our🐠🧙‍♂️#AriAdler and talented #qbio and #mcb undergrad #AlanXu and #KatelynHsu for their help on this study! 9

We were curious about how #TEs would be impacted by #ReproAging, since #TE reactivation is frequent during somatic aging. Because of transgenerational mutagenic potential, dedicated safeguards evolved to keep #TEs in check in the #germline, notably through the #PIWI pathway. 3/n

Really excited to share our latest work, on deciphering #TE control 🧬 during #ReproAging ♀️♂️ in #AfricanTurquoiseKillifish 🐟 [ATK], online today at @genomeresearch@twitter.com! This was spearheaded by talented #DrBryanTeefy in the lab. @USCLeonardDavis@twitter.com A 🧵 1/n
https://genome.cshlp.org/content/early/2022/12/28/gr.277301.122.abstract