In 2022, #StJude scientists advanced research in hemoglobin expression, #cancer survivorship, CAR-T, COVID-19, #smFRET and more. We’re writing the next chapter of St. Jude history through their work. ICYMI, explore some of the accomplishments. http://www.stjude.org/research-news #ResearchWrapUp #YearInReview

To wipe #childhoodcancer off the map, scientists must chart its genomic landscape. Earlier this year, they created a roadmap of the genetic mutations in acute lymphoblastic leukemia. http://bit.ly/3CPxefv
#ResearchWrapUp #StJudeResearch #StJude

Scientists are studying how information transfers from outside to inside a cell. Earlier this year, they discovered how single-molecule imaging gives new insight how GPCRs, a common drug target, send signals. http://bit.ly/3UIKJny #ResearchWrapUp #smFRET #StJude

Health inequities and socio-demographic factors drive more severe symptom burden in childhood cancer survivors. Discover the problems facing nearly half of survivors and the opportunities to improve care. http://bit.ly/3y1Uio7 #ResearchWrapUp #StJude

Earlier this year, #StJude scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias. http://bit.ly/3CudVqd #ResearchWrapUp @Nature

#StJude scientists discovered the developmental origins for Group 3 and Group 4 #medulloblastoma, which may help improve research models and potential therapeutics. http://bit.ly/3S2eT3J @Nature #ResearchWrapUp

Thanks to #StJude scientists, there are improvements in CART T-cell therapy for difficult-to-treat relapsed T-cell acute lymphoblastic leukemia using naturally occurring CD7 negative #Tcells. Learn more. http://bit.ly/3EfGsRw #ResearchWrapUp

Using genetic and clinical risk factors, St. Jude scientists created an assessment tool that can predict which patients have the highest risk of developing obesity as adults—allowing for early lifestyle changes. http://bit.ly/3OA1BJ0 #ChildhoodCancer #ResearchWrapUp @nature

To improve solid tumor treatment, St. Jude researchers altered a central molecular mechanism of #CARTcells and pushed T cells to become long-lasting memory cells instead of short-lived effectors. Learn how they did it. http://bit.ly/3URJPVW @Nature #ResearchWrapUp

To address the issues of big data in rare disease research, St. Jude scientists created CoCoRV—a tool that provides a systematic solution to finding inherited genes that contribute to rare diseases. Learn more. http://bit.ly/3EE4837 #ResearchWrapUp #StJudeResearch

Thanks to research from St. Jude scientists, there is now more information about how the immune system responds to infection and vaccination from the SARS-CoV-2 virus. http://bit.ly/3ECwJ94 #COVID19Research #ResearchWrapUp

As 2022 comes to a close, we’re highlighting some of the ways St. Jude scientists have helped advance research in #oncology, CAR-T, COVID-19 and more. The first in our series: Genetic ancestry of acute lymphoblastic #leukemia. "As a field, we really need to put diversity front and center in our research,” Dr. Jun J. Yang says on why it’s important to consider genetic ancestry to understand global diversity in childhood leukemia. http://bit.ly/3EEIZWA #ResearchWrapUp #ChildhoodCancer