#Angiocrine Lung #Alveologenesis

Cyp26b1, catabolizing #RetinoicAcid, is #EndothelialCell-restricted in 🐭 emb Lung+Kidney

Cyp26b1 KO->
⏬AT1 fate of Sox9+ distal airway epithelial progenitors
⏫septa thickness
⏬Airspace

@ondinecleaver2022 @Dev_journal 2020
https://journals.biologists.com/dev/article/147/4/dev181560/223218/Cyp26b1-is-an-essential-regulator-of-distal-airway

@jaclynmacrae

Some Long Covid symptoms, e.g., alcohol intolerance, could be due to lowered activity of aldehyde dehydrogenase, particularly ALDH2. I submitted a related hypothesis to the Patient-Led Hypothesis Generation Panel which provides background & refs (1).

Inhibition of aldehyde dehydrogenase causes lower sperm count & has been investigated as a means of male birth control (2).

1- https://docs.google.com/document/d/1XBe3xkZLUtcTUZjd07nH97jjL9QR5Vt3YS08zo7WpOY/edit?usp=sharing

2- https://www.bloomberg.com/news/features/2017-08-03/why-we-can-t-have-the-male-pill

#LongCovid #ALDH2 #RetinoicAcid #spermatogenesis