#Ribosomal gatekeepers: Study sheds light on molecular control centers of #eukaryote #protein factories.

#METAP1 #SRP

https://phys.org/news/2023-06-ribosomal-gatekeepers-molecular-centers-eukaryote.html

As someone who identified twenty years ago some of the factors involved in the assembly of the yeast 60S #ribosomal subunit, it is fantastic to see now a structure of a pre-60S particle at its exit from the nucleus through the nuclear pore complex.

Just for fun, the name of one of the proteins that is involved in the pre-60S export is Alb1, a name that comes from "Arx1's little brother" as it is in contact with Arx1.

https://pubmed.ncbi.nlm.nih.gov/37258668/

When individual deletion #yeast strains cannot grow alone, some can be rescued by neighbouring strains producing a critical #metabolite. A search for cross-complementation by co-culture of mutants identified interesting links between, mostly, aminoacid synthesis pathways.

Some of the genetic interaction remain mysterious, such as those involving the deletion of #ribosomal protein genes RPS24B or RPL27A.

https://pubmed.ncbi.nlm.nih.gov/37248413/

A real challenging idea from the Katrin Karbstein's lab: #ribosomal proteins damaged by oxidation are replaced with "fresh" ones to maintain #ribosomes functional. For Rpl10, its association and dissociation from mature ribosomes in the cytoplasm was already known, so it is not clear if the hypothesis put forward in the paper is not a consequence of the shuttling ability of some #proteins assisted by assembly chaperones.

https://pubmed.ncbi.nlm.nih.gov/37086725/

Researchers discover new class of #ribosomal #peptide with #hemolytic activity.

#RiPP #genomics

https://phys.org/news/2023-04-class-ribosomal-peptide-hemolytic.html

Physically separating early steps in #ribosome assembly in the #Ecoli nucleoid from the RNA #degradosome attached to the inner cytoplasmic membrane protects precursor #ribosomal RNA in immature particles from degradation @Lydia_LH17 &co #PLOSBiology https://plos.io/3Qj1x2O

Physically separating early steps in #ribosome assembly in the #Ecoli nucleoid from the RNA #degradosome attached to the inner cytoplasmic membrane protects precursor #ribosomal RNA in immature particles from degradation @Lydia_LH17 &co #PLOSBiology https://plos.io/3Qj1x2O

A nice new #paper where I have played a small part. An extremely surprising finding where mutants in the 5S #ribosomal #RNA #transcription factor #GTF3A causes enhanced #susceptibility to #HSV #virus #infection, leading to #encephalitis. A #pseudogene #transcribed is a #ligand activating #RIG-I.

https://pubmed.ncbi.nlm.nih.gov/36399538/

#fediscience #immunology #science #PID #genetics #signaling #herpes #health