#microRNAs slow translating #ribosomes to prevent protein #misfolding in eukaryotes
Hiroaki Sako, Tadashi Yamamoto and colleagues
The unusual presence of #miRNAs targeting protein-coding sequences is shown to influence ribosome speed, thereby allowing time for accurate #polypeptide folding during protein translation.
https://www.embopress.org/doi/full/10.15252/embj.2022112469

How one of nature's most fundamental molecules forms.

#ribosomes

https://phys.org/news/2023-07-nature-fundamental-molecules.html

The ASC-1 complex is more than a dissociator of colliding 80S ribosomes:

Akinobu Matsumoto, Keiichi Nakayama and coworkers show that it also associates with scanning #ribosomes to promote translation initiation on a subset of transcripts

https://www.embopress.org/doi/10.15252/embj.2022112869

#CryoEM of yeast methionine aminopeptidase & N-acetyltransferase B in complex with #ribosomes reveals involvement of rRNA expansion segment ES27a in orchestrating modifications of nascent polypeptide chains during translation @BeckmannLab #PLOSBiology https://plos.io/3n0S1an

#CryoEM of yeast methionine aminopeptidase & N-acetyltransferase B in complex with #ribosomes reveals involvement of rRNA expansion segment ES27a in orchestrating modifications of nascent polypeptide chains during translation @BeckmannLab #PLOSBiology https://plos.io/3n0S1an

#CryoEM of yeast methionine aminopeptidase & N-acetyltransferase B in complex with #ribosomes reveals involvement of rRNA expansion segment ES27a in orchestrating modifications of nascent polypeptide chains during translation @BeckmannLab #PLOSBiology https://plos.io/3n0S1an

A real challenging idea from the Katrin Karbstein's lab: #ribosomal proteins damaged by oxidation are replaced with "fresh" ones to maintain #ribosomes functional. For Rpl10, its association and dissociation from mature ribosomes in the cytoplasm was already known, so it is not clear if the hypothesis put forward in the paper is not a consequence of the shuttling ability of some #proteins assisted by assembly chaperones.

https://pubmed.ncbi.nlm.nih.gov/37086725/

#CellularPhysiology #CellularFunction #Ribosomes
https://phys.org/news/2023-04-cells-maintenance-crews-protein-factories.html

Study: #Cells send #maintenance crews to fix damaged #protein factories.

#ribosomes #chaperone

https://phys.org/news/2023-04-cells-maintenance-crews-protein-factories.html

Human #ribosomes decode #MessengerRNA 10 times slower than bacterial ribosomes—but do so more accurately. Explore how #StJude #scientists made this discovery. http://bit.ly/3zxa9v8 #cryoEM #StructuralBiology @Nature #mRNA #StJudeResearch

Referenced link: https://phys.org/news/2023-03-exploring-heart-toggles-maintenance-energy-boost.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-03-exploring-heart-toggles-maintenance-energy-boost.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1633163474414206976#m

Exploring how the #heart toggles between maintenance and energy-boost mode using #ribosomes https://apps.crossref.org/pendingpub/pendingpub.html https://phys.org/news/2023-03-exploring-heart-toggles-maintenance-energy-boost.html

Community science designed #ribosomes with beneficial phenotypes | Nature Communications

https://www.nature.com/articles/s41467-023-35827-3

Decoding the special role of a #biogenesis factor in the maturation of precursor #ribosomes.

#RNA #assembly

https://phys.org/news/2023-02-decoding-special-role-biogenesis-factor.html

RT @MichaelCJewett
Beyond proteins, what if we could computationally design ribosomes? @camilakofman @NUSynBio @amw_stanford @RDasLab @__dskim @smashty explore this question in @NAR_Open to make mutant #ribosomes #synbio

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1036/6885013

Amazing new things in biology
1
Bacteria can shed their cell walls to avoid phage
https://mas.to/@ArianeBriegel@mstdn.science/109790007630452316

2
Viroids are everywhere; a ribozyme is the minimal replication unit
https://www.biorxiv.org/content/10.1101/2022.07.19.500677v1

3
Viruses can be REALLY big and encode all sorts of proteins that we thought were cellular

https://www.virology.ws/2019/02/21/ribosomal-proteins-encoded-in-viral-genomes/

#biology #bacteria #virus #dna #proteins #RNA #ribosomes #peptidoglycan #phage

RT @MhkoScience
Together with @CompBioPhys we wrote a review on large-scale MD simulations of biomolecules. We focused on the interplay between simulations and experiments in studying #ribosomes. Now online, enjoy reading.

http://doi.org/10.1146/annurev-biophys-111622-091147

RT @MhkoScience
Together with @CompBioPhys we wrote a review on large-scale MD simulations of biomolecules. We focused on the interplay between simulations and experiments in studying #ribosomes. Now online, enjoy reading.

http://doi.org/10.1146/annurev-biophys-111622-091147

How do #nutrient-starved cells preserve a basal supply of dormant #ribosomes?
Michael Hall and colleagues (Biozentrum Basel) identify conserved #TORC1 #phosphorylation and inhibition of ribosome-binding factor #Stm1/#SERBP1 in #yeast and human cells
https://www.embopress.org/doi/10.15252/embj.2022112344

RT @FriedaLeesch
Our paper on dormant egg ribosomes is out now! I couldn't be more grateful to work with @llorenzoorts,@PauliGroup @HaselbachLab and so many others. I learned so much and discovered my passion for #ribosomes https://www.nature.com/articles/s41586-022-05623-y

Thank you for your enthusiasm and support!

RT @FriedaLeesch
Our paper on dormant egg ribosomes is out now! I couldn't be more grateful to work with @llorenzoorts,@PauliGroup @haselbachlab and so many others. I learned so much and discovered my passion for #ribosomes https://www.nature.com/articles/s41586-022-05623-y

Thank you for your enthusiasm and support!