Benchmarking Continuous Time Models for Predicting Multiple Sclerosis Progression

https://openreview.net/forum?id=2uMnAwWnRy

#predicting #sclerosis #models

Common viral antibodies could trigger #multiple #sclerosis (MS)

📌 The research suggests that the body’s immune response to the Epstein-Barr virus (EBV), a normally harmless infection, can misfire and mistakenly target a crucial protein in the brain and spinal cord.

📌 In some people, these antibodies could be involved in triggering MS.

https://www.theguardian.com/society/2023/may/17/common-viral-antibodies-could-trigger-ms-research-reveals

RT @biobankingcom@twitter.com

Using time series #data from @FinnGen_FI@twitter.com for discovery and cross-sectional @data@twitter.com from the @uk_biobank@twitter.com for replication, #researchers identified...
Read more: https://www.cell.com/neuron/fulltext/S0896-6273(22)01147-3#%20

#Sclerosis #biobank #Alzheimer #neuroscience #neurodegenerative #dementia #diseases @CellPressNews@twitter.com

🐦🔗: https://twitter.com/biobankingcom/status/1616677629108649984

"Multiple Sclerosis: What We Can Learn Even from Failed Approaches to Antibody Therapies": https://doi.org/10.56537/new-ground.2022.13902 - Thorough overview of Julia Krämer and Heinz Wiendl, 2022, in Neurotherapeutics #ASENT #multiple #sclerosis

RT @DiMartinoBooth@twitter.com

#Sclerosis https://twitter.com/lizannsonders/status/1357686493859438602

🐦🔗: https://twitter.com/DiMartinoBooth/status/1357688771479805952

🔴 Demyelinating Diseases

🔸 The #glialcells that make the myelin are of different types that make it (myelin) in the central nervous system and in the peripheral nervous system. And because of that, people who get a demyelinating disease, get it either in the central nervous system or in the peripheral nervous system -- but not in both.

🔸 So the problem is either in the #oligodendrocytes (and the interaction between the oligodendrocytes and the axon) -- in which case you get a central demyelinating disease, and the most common by far is multiple #sclerosis -- or there's a problem in the #SchwannCell and its connection to the axon, and in that case you can get a variety.

🔸 There are a diverse group of hereditary neuropathies called Charcot-Marie Tooth, which are #DemyelinatingDiseases. They're inherited and they typically progress and become worse with time.
🔸 There's also an acute demyelinating disease called Guillain–Barré, which typically has a very quick onset, it's inflammatory, and luckily it goes away after a while.