Referenced link: https://phys.org/news/2023-04-nanoplasmonic-imaging-reveals-real-time-protein.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-04-nanoplasmonic-imaging-reveals-real-time-protein.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1645785902957076480#m
Nanoplasmonic imaging reveals real-time protein #secretion @epfl_en @natBME https://www.nature.com/articles/s41551-023-01017-1 https://phys.org/news/2023-04-nanoplasmonic-imaging-reveals-real-time-protein.html
We found that the #Parkinson's disease related kinase #LRRK2 interacts with vesicular #SNAREs #VAMP4 and #VAMP7. #VAMP4 and #VAMP7 are required for proper processing and release of #Parkinson's disease #biomarkers #VGF as we found using #secretomics. We found late endosomal #secretion of #VGF together with #exosome markers like #CD63. We also developed a #rushassay to study #VGF #trafficking.
#parkinson #lrrk2 #snares #vamp4 #VAMP7 #biomarkers #vgf #secretomics #secretion #exosome #cd63 #rushassay #trafficking
#Secretion of #VGF relies on the interplay between #LRRK2 and post-Golgi v-SNAREs #VAMP4 #VAMP7.
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00232-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723002322%3Fshowall%3Dtrue
#secretion #vgf #lrrk2 #vamp4 #VAMP7
Unconventional #secretion of unglycosylated #ORF8 is critical for the #cytokine #storm during #SARS-CoV-2 infection https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011128
#secretion #orf8 #cytokine #storm #sars
Assembly and architecture of the type III #secretion sorting platform | PNAS
Referenced link: https://phys.org/news/2022-05-molecular-mechanism-secretion-sonic-hedgehog.html
Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1523680403122491394#m
A novel molecular mechanism that regulates #secretion of the sonic hedgehog signaling molecule @hkust @PNASNews https://doi.org/gp4qwr https://phys.org/news/2022-05-molecular-mechanism-secretion-sonic-hedgehog.html