Have any antisense oligonucleotide #ASO experts made it onto mastodon?

I'm trying to find evidence on how much of a role #intron secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the #spliceosome recognizes intron #secstruct, particularly the intron 5' structure, but haven't found published evidence or hypothesis.

#pre-mRNA #splicing