🍂When and how #leaf #senescence occurs is critical for #plant reproductive success and fitness. Here, Chen et al. characterize a transcription factor that regulates age-dependent leaf senescence in #Arabidopsis. https://jipb.net/EN/10.1111/jipb.13434
@wileyplantsci
#JIPB #PlantSci #development #PlantScience

#PhD student studying #pathological
#senescence

Salary:
€ 2.789 - € 3.536 #PhDposition

"We are looking for an enthusiastic and ambitious PhD candidate in the Laboratory of Cellular senescence and age-related pathologies, headed by Prof. Marco Demaria to work on a project studying the contribution of #senescent cells to inflammatory and #fibrotic chronic disease. "

Required : MSc in #Biology

Closing date: August 24 CET

#UMCGroningen #UMCG #Groningen
https://werkenbijumcg.nl/-/vacatures/phd-student-studying-pathological-senescence/10419-02s00088pp

Research Postdoctoral Fellow (Lung Epithelial Repair Lab)

University of Pittsburgh - Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Join our energetic NIH-funded team as a #Postdoc in #Pittsburgh studying #mitochondria, #lung repair and #senescence in lung disease.

See the full job des...
https://jobrxiv.org/job/university-of-pittsburgh-division-of-pulmonary-allergy-critical-care-and-sleep-medicine-27778-research-postdoctoral-fellow-lung-epithelial-repair-lab/?feed_id=49342

Study looks at summer #solstice effect on #leaf #senescence.

#signalling #sensing #climatechange

https://phys.org/news/2023-07-summer-solstice-effect-leaf-senescence.html

Research Postdoctoral Fellow (Lung Epithelial Repair Lab)

University of Pittsburgh - Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Join our energetic NIH-funded team as a #Postdoc in #Pittsburgh studying #mitochondria, #lung repair and #senescence in lung disease.

See the full job des...
https://jobrxiv.org/job/university-of-pittsburgh-division-of-pulmonary-allergy-critical-care-and-sleep-medicine-27778-research-postdoctoral-fellow-lung-epithelial-repair-lab/?feed_id=49223

Scientists discover clues to aging and healing from a squishy sea creature.

#cniderian #Hydractinia #RNA #senescence

https://phys.org/news/2023-06-scientists-clues-aging-squishy-sea.html

Myc and the placenta.
“These data reveal Myc is essential for polyploidy to support normal placental development, thereby preventing premature senescence. “
#placenta #Myc #Trophoblast #senescence #reproduction #DevBio #Science
https://journals.biologists.com/dev/article/150/11/dev201581/316006/Myc-promotes-polyploidy-in-murine-trophoblast

🥥 As I continue to slip into #senescence, I notice that I find it harder and harder to make sense of online charts and especially graphs. 🥥

A new transparent #killifish line called klara, generated using #CRISPR/Cas9, can significantly simplify explorations of #development, #senescence, ageing and #regeneration. #ModelOrganism https://elifesciences.org/articles/81549?utm_source=mastodon&utm_medium=social&utm_campaign=organic

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241

@PeerCommunityIn Now published in Peer Community Journal, #EvolutionaryBiology section: Extrinsic mortality and #senescence: a guide for the perplexed. https://doi.org/10.24072/pcjournal.253

#Splicing factor YBX1 regulates bone marrow stromal cell fate during aging

Reduced expression of #YBX1 in #aging #bonemarrow stromal cells induces their #senescence and bone loss due to mRNA mis-splicing

https://www.embopress.org/doi/10.15252/embj.2022111762

A new #preprint #OpenScience #PeerReview by #PCIEvolBiol de Vries C, Galipaud M, Kokko H (2023) Extrinsic mortality and #senescence: a guide for the perplexed. #bioRxiv #EvolutionaryBiology https://doi.org/10.1101/2022.01.27.478060

AP-1 transcription factors ATF3/FOSL1/FOSL2/c-JUN reshape Chromatin Accessibility landscape during #EndothelialCell #Senescence

HUVEC PD 8vs24vs36
1038 & 964 increased & decreased accessibility regions
>94% >2 kb from TSS

Dr. Wei Tao lab Aging Cell 2021
https://onlinelibrary.wiley.com/doi/10.1111/acel.13315

AP-1 TFs also play pioneering roles in fibroblast #Senescence 🤠

AP-1 imprints a reversible transcriptional programme of senescent cells

Dr. Oliver Bischof lab Nature Cell Bio 2020
https://www.nature.com/articles/s41556-020-0529-5

SenMayo
A 125-gene set (15 studies) for #Senescence/#SASP in Bone/Bone marrow/Adipose/Brain...

#Senolytic readout

vs GenAge & CellAge

MIF as a key SASP gene!

Dr. Dominik Saul, Joshua Farr & Sundeep Khosla labs Nature Comms 2022
https://www.nature.com/articles/s41467-022-32552-1

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

#senescence

https://www.jci.org/articles/view/162519

Pick a publication on cellular #senescence at random and it likely describes something completely new: a hitherto unknown #biomarker to rule them all, a suspiciously overlooked key contribution to age-associated diseases or yet another essential molecular cogwheel. So it’s refreshing to read a manuscript critically analysing previous findings:
Battaglia et al.
Lost in HELLS: disentangling the mystery of SALNR existence in senescence cellular models
https://www.biorxiv.org/content/10.1101/2023.02.03.526712v1
#biorxiv

Postdoctoral Fellow – Senescence Heterogeneity in Mouse Aging and Diseases @NBasisty

Join our dynamic @NIHAging team as a #postdoc working on #senescence in mice!

https://jobrxiv.org/job/national-institute-on-aging-nih-27778-postdoctoral-fellow-senescence-heterogeneity-in-mouse-aging-and-diseases/?feed_id=35723

#ScienceJobs #job #aging #geroscience #AcademicTwitter
Bal...
https://jobrxiv.org/job/national-institute-on-aging-nih-27778-postdoctoral-fellow-senescence-heterogeneity-in-mouse-aging-and-diseases/?feed_id=35723

Senescence of cortical neurons following persistent DNA double-strand breaks induces cerebrovascular lesions

#senescence #ageing #biorxiv #preprint

https://www.biorxiv.org/content/10.1101/2023.01.26.525738v1

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

#senescence #Senolytic

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.058794