New ribozyme can make #RNA molecules accessible for #clickchemistry in living cells https://phys.org/news/2023-09-ribozyme-rna-molecules-accessible-click.html

Damn this is hot - imagine the possibilities for single sell #RNAseq @nanopore
#sequencing

It is fascinating that we get a bunch of biological #sequence #aligners to choose from in #bioinformatics , but no standardized terminology of their modes, or API (you can find a bewildering mix of libraries and CLI). This is gap for researchers who want to try different tools, and likely for companies in the #NGS #sequencing space too. The first is the reason I am flexing my #perl skills , leveraging the new lang features to create a standardized API for many of the recent tools. @Perl

Hello! I was wondering if I am in the right instance for discussions around #ngs and #sequencing. If you know of a more appropriate place, please let me know! Thanks!

The analysis was performed using our SIB Software Resource #Vpipe - the #NGS #bioinformatics pipeline tool for virus #sequencing.
Detection handled by the component COJAC.

More details on our project and procedure available at https://cov-spectrum.org/stories/wastewater-in-switzerland and at https://github.com/cbg-ethz/cowwid
…

#opensource
#snakemake

Open access Symposium now available on the ahead of print page! "Whole-#Genome #Sequencing Reveals That Regulatory and Low Pleiotropy Variants Underlie Local Adaptation to #EnvironmentalVariability in Purple #SeaUrchins" by Petak et al. https://www.journals.uchicago.edu/doi/10.1086/726013

#WHO DG speech: ''...Although #data available to WHO continues to decline, we have seen increasing reports of #hospitalizations, #ICU admissions and #deaths in some countries. We continue to call on all countries to strengthen #surveillance, #sequencing and reporting so we can assess the #risk of new #variants such as #EG5 and #BA286. ...'', https://www.who.int/news-room/speeches/item/who-director-general-s-opening-remarks-at-the-media-briefing---25-august-2023 #SARS_CoV_2 #VOI #pandemic #news

''Now #RIMS has sent the sample to #NIV, #Pune #lab for #sequencing. It has been confirmed from there also. The condition of the child is critical. He has been put on oxygen support.''

Since when did #seqanswers became "a brand of CompareNetworks"?

https://www.seqanswers.com/privacy

This certainly explains the recent influx of spammy emails from them.

#bioinformatics #sequencing

Register today for our Nanopore Day in Copenhagen to hear the latest technical updates from Oxford Nanopore Technologies as well as talks from local and international scientists about their work using nanopore technology in human translational and clinical research.

https://nanoporetech.com/nanopore-day-copenhagen-2023

#genomics #clinicalgenomics #nanopore #sequencing

PacBio has officially commercially released Onso, their new short read, high accuracy DNA sequencer.

The instrument price isn't too bad ($259k), but I can't find the run cost. How much of a premium will people be willing to pay for Q40 (and some Q50) reads. I think we're about to find out.
#DNA #sequencing

https://www.pacb.com/press_releases/pacbio-begins-commercialization-of-the-onso-short-read-sequencing-system/

It was a pleasure to work with Jason Ladner and Jason Sahl on this insightful look at how pathogen genomics can be leveraged post #COVID19 to understand and track other pathogen and emerging #epidemics

#pandemic #genomics #pathogen #virus #bacteria #sequencing #GlobalHealth

From: @PLOSBiology
https://fediscience.org/@PLOSBiology/110819074844875384

How #flies develop #sight: Scientists use single-cell #sequencing to identify #cell types in the visual system.

#drosophila #RNA #split_GAL4

https://phys.org/news/2023-07-flies-sight-scientists-single-cell-sequencing.html

New resource harmonizes #16S and #shotgun #sequencing data for #microbiome research.

#Greengenes2 #metagenomics

https://phys.org/news/2023-07-resource-harmonizes-16s-shotgun-sequencing.html

#Bacterial single-cell, whole-#genome #sequencing overhauled by engineered #polymerase.

https://phys.org/news/2023-07-bacterial-single-cell-whole-genome-sequencing-overhauled.html

Expanding the tree of life - hear all about the latest discoveries at: 2023 NeLLi - New Lineages of Life Symposium

Great speakers, back to back with the annual Joint Genome Institute (JGI) meeting.

Register now: https://usermeeting.jgi.doe.gov/2023-nelli/

@LBNLBioSci #genomics #microbiology #bioinformatics #sequencing #evolution

Genome skimming for global DNA methylation done with @nanopore. Super accurate, repeatable, easy-to-do and inexpensive. Works across all animals! Transposon methylation too! #epigenetics #sequencing https://pubmed.ncbi.nlm.nih.gov/37442577/

#Sequencing #Europe's #Biodiversity: #ERGA's mission to Compile a European Atlas of Reference Genomes

https://www.erga-biodiversity.eu/post/sequencing-europe-s-biodiversity-erga-s-mission-to-compile-a-european-atlas-of-reference-genomes

#genome @erga_biodiv

Cool computational method for separating γδ #Tcells by #rna #sequencing
Rather than relying on paired #TCRseq or #CITEseq, they calculate module scores of TCR constant and variable regions

https://doi.org/10.1093/jleuko/qiad069

Whole genome sequencing is becoming ubiquitous and financially accessible. As third party companies offer a detailed and often convoluted snapshot of our molecular composition, we are tasked with interpreting this in our own health and wellbeing. What starts as general curiosity turns into a list of further tests and investigations; the medicalisation and institutionalisation of our inquisitiveness. And at whose cost? #health #medicine #genome #sequencing #gene

New NIOO publication: Dynamic effects of #probiotic formula ecologic®825 on human small intestinal #ileostoma #microbiota: a network theory approach. #gutmicrobiota #metabolites #sequencing
https://doi.org/10.1080/19490976.2023.2232506