Understanding tissue morphology is crucial for normal physiological function, and we are excited to see how #SimuCell3D can help advance this field!

#tissuemorphology #cellularmechanics #opensourcesoftware #biomechanics

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#SimuCell3D can be used to #infer the cell #mechanical #properties that lead to an imaged tissue geometry.

The cell shapes were extracted from microscopy images: https://twitter.com/DagmarIber/status/1639171212449308672.

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RT @DagmarIber
As theoretician, I am excited to share the 1st experimental protocols paper from my lab
"Time-lapse and cleared imaging of mouse embryonic lung explants to study 3D ce…
https://twitter.com/DagmarIber/status/1639171212449308672

We also apply #SimuCell3D to the study of two morphogenetic problems: the formation and maintenance of #layered #epithelia and the cellular organization in a #pseudostratified epithelium.

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In our paper, we present the strategy used to represent the #biomechanical and geometrical state of cells, and demonstrate the computational efficiency and versatility of #SimuCell3D by simulating various tissue topologies.

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#SimuCell3D natively integrates intra- and extra-cellular entities, including #ECM, #nuclei, #lumens, and #polarised cell surfaces.

Users can #customise #SimuCell3D to their specific research questions.

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#SimuCell3D can simulate the #growth of tens of thousands of cells in a single day of computing time.

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#SimuCell3D can contribute to this understanding by creating highly realistic #digital #twins of #tissues.

This allows users to investigate how the #cell properties and behaviours impact tissue morphologies.

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Excited to introduce #SimuCell3D, an #opensource 3D cell-based model to simulate large and complex tissues at high resolution.

Check out our latest @biorxivpreprint https://doi.org/10.1101/2023.03.28.534574

A short summary thread about the software tool:🧵(1/9)