RT @XChemInc
DELs, a faster way to tap into the ubiquitin-proteasome system. In supporting @Relay_Tx and @thesgconline, our high-quality DEL data facilitated the discovery of a promising #smallmolecule engager for DCAF1. http://ow.ly/qNMq50NL2Vm

#DEL #drugdiscovery

2017 paper, A dynamic map for learning, communicating, navigating and improving therapeutic development
#smallmolecule #drugdevelopment

https://www.nature.com/articles/nrd.2017.217

@KRHornberger

Thanks, I've read that paper!

Glad to have another option, I always enjoy your commentaries and tutorials. They remind me of my #SmallMolecule #ADME days.

An interesting point on #drugdiscovery
“.... How do we truly define a #smallmolecule #drug today? ... Are #chemists making the “wrong” kinds of molecules?
Or have we entered a new era of drug modalities?
.... And just to prove chemists can continue to make the “right” kinds of molecules, here are some recent low Mw drug #approvals -
-       Tecfidera (Mw 144), #FDA approved 2013
-       Tavaborole (Mw 151), FDA approved 2014
-       Avibactam (Mw 265), FDA approved 2015
-       Benznidazole (Mw 260), FDA approved 2017
-       Migalastat (Mw 163), FDA approved 2018
 
How many novel small molecule drugs Mw<300 are yet to be discovered?”

https://www.linkedin.com/posts/trevor-brett-a09721131_medicine-pharmaceuticals-healthcare-activity-7003780928837672960-lqc1?utm_source=share&utm_medium=member_ios