#CryoEM models of spliceosomal complexes containing Prp16 show it in its nucleotide-free state: here the first structure of Prp16 in complex with a nucleotide is presented.
@unigoettingen

@ActaCrystF

@IUCr
#DEAHBoxHelicases #Prp16 #spliceosome https://doi.org/10.1107/S2053230X23005721

LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis

Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8

https://www.embopress.org/doi/10.15252/embj.2022110921

Excited to announce Eterna has launched our new OpenASO project in collaboration with the Sanford and Stone Labs at UC Santa Cruz.

Our players will be designing short pieces of #RNA to restore proper splicing in pre-mRNA mutated by #genetic disease and learn more about #exon definition.

https://www.youtube.com/watch?v=Iq57MTprHV0

#chemistry #biochemistry #raredisease #hemophilia #spliceosome #crowdsourcing #citizenscience

Have any antisense oligonucleotide #ASO experts made it onto mastodon?

I'm trying to find evidence on how much of a role #intron secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the #spliceosome recognizes intron #secstruct, particularly the intron 5' structure, but haven't found published evidence or hypothesis.

#pre-mRNA #splicing

RT @HouartLab
🚨New research from our lab discovers surprising axonal roles for a major #spliceosome protein during motor connectivity in #zebrafish. @nikolas_neuro @CorinneHouart
Read more here👇👇: https://bit.ly/3EdukAx

Enjoy these five seconds of extra fall colour from our #spliceosome lesson in Unit 3 | Genetics from our #introductory #biology LIFE #animated #textbook. #NotYourOrdinaryBiologyTextbook Request your trial today! https://www.smart-biology.com/request-trial/ https://twitter.com/SmartBiology3D/status/1589633786194673668/video/1