The #ssNMR analysis was used (among several other techniques) to probe the time-dependent changes in chemical structure during the polymerization process.

A new paper by our colleagues from the Zernike Institute (U. Groningen) has just been published, including some #ssNMR from my group. The paper looks at the process of polydopamine formation the presence and absence of halloysite #nanotubes. See the paper here: https://doi.org/10.1038/s41467-023-36303-8 #polymers

Coming on Thu Feb 2nd: a special online workshop on handling and studying of fibrillar and #amyloid proteins. With presentations by Per Hammarström (Linköping, Sweden), Beat Meier (ETH, Switzerland), Stefano Ricagno (Milan, Italy), Byron Caughey (NIH, USA), and myself (Groningen). Topics: #prion propagation & seeding, structural studies by #ssNMR and #cryoEM, toxicity and biosafety. See #biophysics MOSBRI website: https://www.mosbri.eu/events/workshop-handling-fibrillar-and-amyloid-proteins/

The MOSBRI network (https://www.mosbri.eu ) is a Europe-wide molecular-scale #biophysics research infrastructure network. Biophysics groups at our university (#Groningen) participate with capabilities in single molecule studies, AFM, and #ssNMR: https://www.mosbri.eu/partners/rug-bp/ . Our network offers funds for trans-national access (TNA). So please reach out if you are curious about trying #ssNMR studies of your e.g. protein aggregates, #amyloid or membrane-bound proteins.

Nice new review article on "Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy: Advances in Methodology and Applications" by Nishiyama, Hou, Su, & Ramamoorthy - ACS journal Chem. Rev: https://pubs.acs.org/doi/abs/10.1021/acs.chemrev.2c00197 #nmrchat #ssNMR

@AnsgarSiemer It is a pity that these #ssNMR experiments do not distinguish different #tau #amyloid conformations, such as the #AD and #AGD folds. Would #NOE distance measurements help, or is that not possible for these samples?

Our department at the Zernike Institute for Advanced Materials of the University of #Groningen is highlighting Raffaella Parlato from my #SSNMR group in this year's advent calendar: Raffaella's research focuses on #HuntingtonsDisease, a rare and neurodegenerative disease caused by #polyQ #protein aggregation into #amyloid fibrils . Read more: https://www.rug.nl/research/zernike/news/newsitems/20221220-day20-parlato

Now online in pre-proof status, at the journal #SSNMR : a new collaborative paper on #DNP ssNMR at 13C natural abundance: "Fast magic angle spinning for the characterization of milligram quantities of organic and biological solids at natural isotopic abundance by 13C–13C correlation DNP-enhanced #NMR" . With Gaël De Paëpe, Snorri Sigurdsson and Sabine Hediger. Includes some new data of unlabeled #polyQ #amyloid aggregates. https://www.sciencedirect.com/science/article/pii/S0926204022000790 #nmrchat

"Aromatic ring flips in differently packed ubiquitin protein crystals from MAS #NMR and MD" by @schandalab - a nice new paper on probing #dynamics by ssNMR. https://doi.org/10.1016/j.yjsbx.2022.100079 in the Journal of Structural Biology X - special issue on solid-state #NMR ( #ssNMR #NMRchat )

Came across this 30-year-old pic. Such a shame there is no longer a commercial DOR probe. When it works, it is indeed doubly magical.

#ssnmr #nmrchat

A belated #introduction here - I am an associate professor at the University of Groningen (Netherlands). My research centers on solid state #NMR ( #ssNMR ) and how to best use it in (structural) biology and materials science. A special focus of my research has been on Huntington disease, where we study how #polyQ proteins form #amyloid like fibrils. In recent years we are also doing an increasing amount of SSNMR on materials (since I joined the Zernike Institute for Advanced Materials )

I was here to discuss how #SSNMR is useful for studying #amyloid proteins. Part of a nice workshop with interesting talks and great discussions.

Simulate and Fit your NMR spectra in Python

Check out the latest mrsimulator, v0.70, at

http://mrsimulator.readthedocs.io

#nmrchat #ssnmr

view the Python notebook that generated the plot below at

https://mrsimulator.readthedocs.io/en/stable/fitting/1D_fitting/plot_3_Na2SiO3.html#sphx-glr-fitting-1d-fitting-plot-3-na2sio3-py

#introduction #intro #NMRchat
Hello world, I am a researcher at the National High Magnetic Field Laboratory. I'm a theoretician by accident, in love with #compchem and spin dynamics simulations, but I can still understand basic organic chemistry. I use my skills to explain what's going on in #MASDNP #DNPNMR experiments and make new molecules to make it better. Welcome to my world made of a mixture of #EPR and #ssNMR, organic chemistry, material science and sometimes biology.