Moderate cold is sensed by #TRPM8 channels, but what about extreme cold?
Peter McNaughton, Tamara Buijs et al at Kings College London identify a #STIM1-#ORAI-mediated mechanism in sympathetic #neurons that may prevent #frostbite through cold‐induced#vasodilation
https://www.embopress.org/doi/10.15252/embj.2022111348