Fresh from the press 📰! Spearheaded by Isabel from H. Prüss' group, our article explores synapsing autoantibodies and their link to fetal abnormalities. We found a 13.3% prevalence of anti-syn in pregnant women, which was associated with neurodevelopmental disorders. Check out Figure 3, where we reveal patient-specific epitopes. 🧠🔬 #autoimmunity #peptides #synapses

https://rb.gy/w22v7

Next is Melanie Samuel from BCM
https://thesamuellab.org/

Molecular regulation of #immune cell #plasticity and function in the #brain

"Our brain is the ultimate time machine" 🙂

How to target #synapses (for intervention) while preserving them (to avoid "turning back the clock"

Possibility that #microglia could be harnessed

partnered with IMPC (impc.org) to find microglia regulators in retina
one cool hit: SIRPα
it's NOT involved in #phagocytosis... surprise

#CSSingleCells23

1/2

#KelseyMartin - How Do #Brains Act?

https://www.youtube.com/watch?v=xeI4W3uJA4A&ab_channel=CloserToTruth

#PhilosophyOfScience #Science #Neuroscience #Seaslug #Neuron #Neurons #ElectroPhysiology #Synapse #Synapses #Serotonin #Neurotransmitter #Neurotransmitters #CloserToTruth #RobertKuhn

2nd attempt at Mastodon after the latest twitter limits -- account just migrated over from #ScienceMastodon, so time for a new #introduction?

7th year (it's time to graduate) PhD candidate in #neuroscience at NYU in the @schoppik lab with interests in #development #circuits #synapses #zebrafish #teaching and all things #evodevo / circuit assembly & function.

I also follow #baseball and am a recently converted #redsox to #phillies fan until the Sox give me something to root for 😂

Little vesicle animation. No receptors yet.

#synapses #glutamate

In case you are in Paris at the end of the month and interested in #synapses, I shall give a talk about tools and methods for #glutamate imaging at the Vision Institute on 30th June. #neuroscience #optobiology

https://www.institut-vision.org/en/our-seminars/815-seeing-glutamate-at-central-synapses.html

#Synaptic #purring: it is when the #synapses in the #brain of a #cat fire #rhythmically in such a way that they cause the cat to produce an otherworldly #purr.

Oh, only if this were a thing... the above is courtesy of me misreading the term "synaptic pruning." 😭

In my defense the #toot was #boosted by a cat, so I was primed to read it that way. 🤔

#SynapticPruning #MisreadToots

Referenced link: https://medicalxpress.com/news/2023-05-brain-protein-destruction-machine-synapses-potential.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-05-brain-protein-destruction-machine-synapses-potential.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1661794266190950400#m

RT by @physorg_com: The brain's #protein-destruction machine learns new tricks at #synapses, potential target for neurological treatments @sciencemagazine https://www.science.org/doi/10.1126/science.adf2018 https://medicalxpress.com/news/2023-05-brain-protein-destruction-machine-synapses-potential.html

What aspect of #trisomy21 underlies the brain disorders of #DownSyndrome? @byneuron @jenkins_paul &co show that the increased inhibitory #synapses in the #neocortex of Down syndrome mouse models is caused by raised levels of DSCAM. #PLOSBiology https://plos.io/43OjKfd

What aspect of #trisomy21 underlies the brain disorders of #DownSyndrome? @byneuron @jenkins_paul &co show that the increased inhibitory #synapses in the #neocortex of Down syndrome mouse models is caused by raised levels of DSCAM. #PLOSBiology https://plos.io/43OjKfd

What aspect of #trisomy21 underlies the brain disorders of #DownSyndrome? @byneuron @jenkins_paul &co show that the increased inhibitory #synapses in the #neocortex of Down syndrome mouse models is caused by raised levels of DSCAM. #PLOSBiology https://plos.io/43OjKfd

Intracellular NASPM blocks outward currents in GluA2-lacking AMPA receptors, with no relief at all from a large panel of auxiliary proteins. Important new tool for identifying AMPAR diversity at synapses. We need more ways to peel off the different types! Nice paper from Ian Coombs in the Cull-Candy-Farrant lab at UCL
https://elifesciences.org/articles/66765

#ionchannels #glutamate #synapses #synapticdiversity #electrophysiology

Spark lasers - new to me, Alcor is a range of compact fiber lasers for #multiphoton imaging.
On the photostimulation side, I suppose that the 780 nm is too "red" for MNI-glutamate uncaging but did anyone try?

https://spark-lasers.com/produit/alcor/

#uncaging #imaging #synapses

A synapse-by-synapse map of a brain

Complete synaptic-resolution connectomes have until now only been mapped for three organisms with up to several hundred brain neurons. Winding et al. describe a three-dimensional electron microscopy–based reconstruction of the larval fruit fly brain. The brain of the Drosophila larva has an order of magnitude more neurons, an even greater scale more synapses, and a complex brain organization.

#Neuroscience #Brain #Connectome #Connectomics #Synapses #Synaptic #Drosophila

https://www.science.org/doi/10.1126/science.add9330

Lung cancer cells and neurons form a dangerous alliance!

A collaborative study from the Bergami lab, Hans Christian Reinhardt, the Motori lab and Beleggia lab shows bona fide synapses between small cell lung cancer and neurons. #preprint

Check out Jade Chan’s #prelight!

👀 https://prelights.biologists.com/highlights/functional-synapses-between-small-cell-lung-cancer-and-glutamatergic-neurons/

#cancer #lung #neurons #synapses

A novel player regulating mitochondrial stabilisation in the dendrites: A proteomic screen uncovers the role of VAP in tethering #mitochondria for continuous fuel supply during synaptic activity.

👀 https://prelights.biologists.com/highlights/vap-spatially-stabilizes-dendritic-mitochondria-to-locally-fuel-synaptic-plasticity/

Kritika Mehta #ZhangLab highlights a #preprint from Vidhya Rangaraju and team in her first #preLight.

Includes authors’ responses ✏️

#neuroscience #synapses #dendrites #plasticity #mitochondria

There are at least 100 trillion neural connections, or synapses, in the human brain. That is at least 1,000 times the number of stars in our galaxy.

#science #sciencefacts #synapses #neuralconnections

https://www.discovermagazine.com/health/numbers-the-nervous-system-from-268-mph-signals-to-trillions-of-synapses

An amazing feeling to get this work into print. The preprint has been available for a long time. I'm glad people could already use it. #openscience

Congratulations to the team!
#tootorial to follow...
#neuroscience #fluorescence #synapses

Targeted sensors for glutamatergic neurotransmission
https://elifesciences.org/articles/84029

RT @quorumetrix
I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines.
#b3d

RT @quorumetrix
I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines.
#b3d