The EMBO Journal · @embojournal
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage
#molecular #syntheticlethality #helicase #wrn #mismatchrepair #MMR #cancer #microsatellite #biochemcial #cruciform #dna #slx1 #slx4 #endonuclease