When validating your therapeutic target, don't forget to check whether there is a commonly occurring non-pathogenic mutation that may impair your intended MoA!

#targetdiscovery #drugdiscovery #oncology OmicsChart #omicschart #clinicalresearch

New publication alert in Cancer Discovery (@CD_AACR@twitter.com), of a study I was involved in! Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha; see https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0244/716349/Discovery-of-Targets-for-Immune-Metabolic, in cooperation with Avinash Sahu, Xiaoman Wang, @PhillMunson@twitter.com, @FisherLabMGH@twitter.com, Keith Flaherty et al, and me and my colleagues at Lead Pharma. #cancerresearch #cancer #tumorimmunology #targetdiscovery #drugdevelopment