Postdoctoral Positions in Plant Proteostasis

RWTH Aachen University

Postdoctoral Positions in Plant Proteostasis to study #ubiquitinsignalling #endocytosis #targetedproteindegradation at the @RWTH in the @TrujilloLab

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=52035

#Science...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=52035

Postdoctoral Positions in Plant Proteostasis

RWTH Aachen University

Postdoctoral Positions in Plant Proteostasis to study #ubiquitinsignalling #endocytosis #targetedproteindegradation at the @RWTH in the @TrujilloLab

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=50851

#Science...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=50851

Out now in CDD: our work in collab with https://www.uni-wuerzburg.de/rvz/forschungsgruppen/ag-friedmann-angeli/ spearheaded by Thamara Nishida Xavier da Silva about in vitro, in silico and biophysical characterization of FSP1 inhibition #Ferroptosis #CellDeath

https://www.nature.com/articles/s41419-023-05787-z

MST and "iFSP1-Tracer" made it possible to quantify binding affinities of the highly hydrophobic inhibitor. The piperazine exit vector (A) could be a starting point for #targetedproteindegradation of FSP1. Huge thx and congrats to everyone involved!

Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3

https://www.nature.com/articles/s41589-022-01218-w
Nice addition to the #targetedproteindegradation literature but I wouldn't describe it as "a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome" since Janse and Church first described this approach in 2004. https://pubmed.ncbi.nlm.nih.gov/15039430/ #PROTACs

Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson

The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease

...
https://jobrxiv.org/job/university-of-california-san-diego-27778-postdoctoral-fellow-in-medicinal-chemistry-chemical-biology/?feed_id=32868

Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity. Very nice PROTAC SPPS synthesis https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01659 #targetedproteindegradation

A Comprehensive Overview of Small-Molecule Androgen Receptor Degraders: Recent Progress and Future Perspectives https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01487#.Y42k0C_-MxQ.twitter #targetedproteindegradation

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets https://pubs.acs.org/doi/10.1021/jacs.2c09255#.Y4dhtUEUjOI.twitter #targetedproteindegradation

#introduction I am a research scientist at the #BroadInstitute in #Cambridge with an interest in #Ubiquitin #ligase #structuralbiology and #mechanisms. Here for the #science toots about #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #CryoEM

After some year now it's time to tweet about my former work. Today we publish a patent with a nice PROTAC approach on PXR nuclear receptor. This receptor, well knew, have not a real antagonist. So, we were decided to make a PROTAC for this target. From in-house agonist, we make a PROTAC. Tricky challenge. And after many synthesis efforts, some PROTAC have showed interesting PXR degradation. And some in-vivo results validate this approach. https://bit.ly/3GH6aku #targetedproteindegradation

DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs https://www.nature.com/articles/s41467-022-34807-3 #targetedproteindegradation

It's really nice to be recognized again this year as a highly cited researcher. I thank the #targetedproteindegradation community for this honor.
#TPD #chemicalbiology

https://clarivate.com/highly-cited-researchers/

Hi Mastodon, I'm Geordi! I'm a #medchem/#chembio PhD student in Scott Prosser and Patrick Gunning's labs at the University of Toronto Mississauga! Lately, I've taken an interest in #targetedproteindegradation and I wrote a chapter on molecular glue degraders in MCB: Biomolecular Interactions! (1/2)
https://www.sciencedirect.com/science/article/pii/S0091679X22000012?via%3Dihub

The lysosomal degraders https://www.nature.com/articles/s41587-022-01594-7 #targetedproteindegradation #targetproteindegradation

PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids https://www.sciencedirect.com/science/article/pii/S2211383522003197 #targetedproteindegradation #targetproteindegradation

The eBook of Inducing Targeted Protein Degradation (Ed. Philipp Cromm, published by Wiley-VCH) is now available! Get yours today. Featuring a chapter by me and Erika Araujo. Print edition coming in December. #TPD #TargetedProteinDegradation #PROTAC
https://www.wiley.com/en-gb/Inducing+Targeted+Protein+Degradation%3A+From+Chemical+Biology+to+Drug+Discovery+and+Clinical+Applications-p-9783527350179

Old target New PROTAC 😉from
@KymeraTx CDK2 PROTAC https://bit.ly/3hEWJYl #targetedproteindegradation

@Laconde I love this story.#targetedproteindegradation

Hi Mastodon world. I am a recently retired Molecular biologist/in vitro pharmacologist. I spent the last 4 years researching mRNA therapeutics and vaccines at Translate Bio, now a Sanofi company. I have also done some #targetedproteindegradation research. I am here to keep involved with some of the ongoing research as I am not ready to completely walk away from science. I look forward to reading about all the advances everyone will make!