#IDMastodon @cellreports #Cellimmunity #Tcellimmunity of vaccinated individuals against #omicron sub~variants remains largely intact due to the nature of polymorphic cell-mediated immune responses, may continue to contribute to prevention/limitation of severe #COVID19 manifestation. The findings are supportive for the suitability of Omicron BA.4/BA.5-adapted #CovidVaccines to boost neutralizing activity against some BA.4/BA.5-descendant variants.

As such, these data suggest minimal indications of antigenic sin effects or functional exhaustion of #Tcellimmunity despite repetitive antigen exposure & solid immunological imprints by ancestral #SARSCoV2 #mRNA vaccination

📌Additive effects of booster mRNA vaccination and #SarsCoV2 Omicron infection on #Tcellimmunity across immunocompromised states
https://www.science.org/doi/10.1126/scitranslmed.adg9452

#IDmastodon #OmicronVariant / subvariants are even more capable than other VOCs in suppressing MHC I expression to evade CD8 #Tcellimmunity 🧵by @virusesimmunity
📌https://twitter.com/virusesimmunity/status/1645769861438529538?s=61&t=Yz-0chnQVfpDSt8bfrGiCw
📌https://www.pnas.org/doi/10.1073/pnas.2221652120
📌 https://www.pnas.org/action/doSearch?ConceptID=500365&startPage=0&sortBy=Earliest