Treg cells are a category of T cells whose properties make them a candidate for potential treatment therapies for #IBD. We eagerly await the outcome of clinical trials using this approach that are currently underway.

#crohns #crohnscolitis #crohnsandcolitis #inflammatoryboweldisease #treg #tcells #tcell

This is especially misleading with the current surge of COVID cases in the U.S. #covid #covid19 #immunity #tcells #LongCovid

How #Tumors Tire Out #TCells;
Researchers investigated how #cancer antigenicity drives unique forms of #Tcell exhaustion and hypofunctionality.
https://www.the-scientist.com/research-briefs/how-tumors-tire-out-t-cells-71224

Turns out the thymus IS important after all - who would have guessed? 😅

https://www.nejm.org/doi/full/10.1056/NEJMoa2302892

#thymus #tcells #immunology

Ars Technica: T cells burn out just a few hours after encountering cancer tumors https://arstechnica.com/?p=1959111 #Tech #arstechnica #IT #Technology #immuneresponse #immunotherapy #Science #t-ceels #Health #cancer #tcells

"Our research suggests that T cells in tumors are not necessarily working hard and getting exhausted. Rather, they are blocked right from the start. This is because the negative signals cancer cells send out to their surrounding environment induce T cell dysfunction, and a lack of positive signals like inflammation results in a failure to kick T cells into high gear."
https://theconversation.com/immune-cells-that-fight-cancer-become-exhausted-within-hours-of-first-encountering-tumors-new-research-210947
#cancer #immunology #tcells

#IDMastodon #Neuroimmunology #Neurocovid @frontimmunol
Compelling evidence for a causal effect of #COVID19 phenotype on AQP4+ NMOSD, shedding new light on the understanding of the comorbidity between #COVID19 & #neuromyelitisopticaspectrumdisorder . The underlying pathogenesis is that #SARSCoV2 infection of multiple cells, macrophages, neutrophils & dendritic cells, induces an #immuneresponse in #Tcells & #Bcells

@jessicawildfire
this is truly a #phenomenal #resource

This section has 35 great links #threads #CovidPapers about #TCells #immuneSystem

Many I’ve seen before, but to have it organized in one place is #priceless #gold

#airborneAIDS is extremely controversial, but think it’s apt

Can understand the anxiety of not wanting to accept #reinfection or infection of #SARS2 is fatal but it’s sheer stupidity to ignore🐘

This is why nobody likes me, & you know what, I really don’t care🖤🖤

An enzyme named IKK ensures the survival of naïve #Tcells by both repressing cell death programs and activating cell survival pathways, according to new findings in @SciSignal. #Immunology https://scim.ag/3kx #press

An enzyme named IKK ensures the survival of naïve #Tcells by both repressing cell death programs and activating cell survival pathways, according to new findings in @SciSignal. #Immunology https://scim.ag/3if #press

This July 4 was hot. #Earth’s #Hottest day on record, in fact. : Wash Post

A #CRISPR-based method makes #TCells that thwart teens’ cancer : Nature

#Chemists discover why #Photosynthetic light-harvesting is so efficient : MIT

Check our latest #KnowledgeLinks

https://knowledgezone.co.in/resources/bookmarks

'While CCR7 is known to promote thymocyte medullary entry and negative selection, our previous studies implicate CCR4 in these processes, raising the question of whether CCR4 and CCR7 play distinct or redundant roles in central tolerance.'

#Immunology #Thymus #Tcells

https://elifesciences.org/articles/80443

New @SciSignal experiments reveal how “sticking” to specific molecules facilitates the activation of #Tcells—potentially explaining how these immune cells are activated as they migrate into inflamed tissues. #CalciumSignaling https://scim.ag/3eB #press

New @SciSignal experiments reveal how “sticking” to specific molecules facilitates the activation of #Tcells—potentially explaining how these immune cells are activated as they migrate into inflamed tissues. #CalciumSignaling https://scim.ag/3bl #press

While #COVID19's impact on #Tcells is not equivalent to the devastation caused by #HIV, it does make individuals more vulnerable to various infections. The loss of T-cells results in increased susceptibility to other viruses and bacteria, often leading to more severe illnesses. #EpiVerse https://www.therecord.com/news/waterloo-region/immune-systems-seriously-weakened-by-covid/article_b8e6b928-f925-583b-8582-e12ef8cea80e.html

Researchers in @SciSignal show that metabolic pathways found in conventional #Tcells are also active in mucosal-associated invariant T (MAIT) cells–potentially informing the development of MAIT cell-based therapies and the study of #obesity. https://scim.ag/2tw #press

#IDMastodon @cellcellpress #Viralimmunology #SARSCoV2 evolved to evade recognition by CD4+ #TCells & increased in its proliferative capacity during the persistent infection which raises the possibility of the emergence of such variants in future even in immunocompetent patients, particularly when the escape from neutralizing #antibodies is not sufficient for immune evasion.
📌https://www.cell.com/iscience/fulltext/S2589-0042(23)00762-9

RT @GrohJanos
Happy to share the final version of our article on mutant myelinating #glia, #neuroinflammation, #axon degeneration, and CD8+ CNS-associated #Tcells in @iScience_CP: https://doi.org/10.1016/j.isci.2023.106698
Many thanks to everyone involved! https://twitter.com/GrohJanos/status/1613097076153262082

https://www.science.org/doi/10.1126/science.abp9563 “Engineered #StaphEpidermidis generated #tumor-specific #Tcells that infiltrated and reduced the growth of localized and metastatic #melanoma. In combination with immune checkpoint inhibitors, these engineered skin bacteria caused mice to reject established tumors. These findings suggest that immune responses from engineered commensals may have therapeutic potential against other tumor antigens of interest.”

This week in @sciencemagazine: Y. Erin Chen, Michael Fischbach & colleagues engineered a strain of #skin #bacteria to express #melanoma #tumor antigens to generate tumor-specific #TCells & enhance anti- #cancer #immune responses in mice!

bit.ly/Sci_abp9563

Perspective by Sajjath, Gola, & Fuchs!

bit.ly/Sci_adh3884