TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH
#plosbiology #tdp43 #FTD #frontotemporaldementia #Als #amyotrophiclateralsclerosis #unc13a
TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH
#plosbiology #tdp43 #FTD #frontotemporaldementia #Als #amyotrophiclateralsclerosis #unc13a
TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH
#plosbiology #tdp43 #FTD #frontotemporaldementia #Als #amyotrophiclateralsclerosis #unc13a
RT @karchlab: Mechanism of #STMN2 cryptic splice-polyadenylation and its correction for #TDP43 #proteinopathies - https://www.science.org/doi/10.1126/science.abq5622 #dementia
#stmn2 #tdp43 #proteinopathies #dementia
#she believed she could, so #she did. Dr. Virginia Man-Lee @PennMedicine #breakthroughprize #TDP43
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RT @PennMedicine
Dr. Virginia Man-Yee Lee is one of the world’s most renowned researchers. But as a woman #STEM, Dr. Lee had to work harder to prove her value throughout her career.
Read her inspiring story and advice for rising female scientists:
#womenshistorymonth
http://spr.ly/60193xoHc
https://twitter.com/PennMedicine/status/1631774199277658114
#womenshistorymonth #stem #tdp43 #breakthroughprize #she
RT @YCharOS1
Another #antibody report is now available!
Visit our community on Zenodo to discover how commercial antibodies targeting TDP-43, a protein associated with ALS, perform in WB, IP, and IF!