Dear ILD Community,

I am pleased to share with you our recently published article:

🚨Genetics and environmental factors in interstitial lung diseases: current and future perspectives on early diagnosis of high-risk cohorts 🚨

Great teamwork! Many thanks Stefan Stanel and Jack Callum 👏👏 #ManchesterILDteam

#Genetics #ILD #FPF #telomere 🫁🧬

https://www.frontiersin.org/articles/10.3389/fmed.2023.1232655/full

@sidereal 😳
I’d bet money most people have no idea that grey/white hair is a sign of #telomere shortening

I certainly was #clueless & used to scoff at my spouse for claiming I stressed him out which is why he said his hair was graying. In retrospect feel quite awful.. alas. (I’m so much a better person after disowning my entire family😂🌈)

They’ve normalized #diabetes in kids #summerColds #influenza twice a year so nothing will shock me, but somehow they’ll surely find a way

https://archive.ph/2023.05.05-131744/https://www.wsj.com/amp/articles/millennials-turning-40-feeling-old-1df2c83b
This is some next level #gaslight -ing🙄🙄🙄🙄🙄🙄

Tbh at 46 feel legitimately 28 despite these sudden white hairs from #Covid #telomere damage. Felt older in my 30’s #diet #inflammation #pfa

Idk how am still constantly surprised at stupidity of people, but consistently shocked at excuses. IT’S OBVIOUS WHAT THE PROBLEM IS YOU MORONS!
Like, you don’t even need to be that astute when it’s hitting you across the face. But no.. it’s the vaccines,co-morbidities, aging, bad air, genes

don’t worry & don’t look up🙄

https://www.biorxiv.org/content/10.1101/2023.07.18.549478v1
#acceleratedAging #telomere
Oh yay another pre-print on something that was already covered last October🙄

Literally no amount of science will get these people to #wearADamnMask

They don’t give a damn about themselves, so we expect them to care about the rest of society?

Taken me⏱️⏱️to conclude💯 b/c infectious disease isn’t fashion forecasting, but we are in absolute dire demise circumstances w/ free for all #Covid #SARS2 #mutations #Bidenomics

GIVE US UNFETTERED ACCESS TO #novavax now

PhD offer alert 🚨
New PhD position open at CEBC Chizé, France.

Come work with F. Angelier, C. Barbraud, O. Chastel to study the relevance of #telomere length as a proxy of health in #seabirds
🇦🇶❄️🐧🔬🧬
Starting October 1
#PhDposition
Message F. Angelier if interested https://www.cebc.cnrs.fr/ecophy/frederic-angelier/?lang=en

RT @FAngelier
PhD offer alert 🚨
New PhD position open @CEBC_ChizeLab
Come work with @FAngelier C. Barbraud O Chastel to study the relevance of #telomere length as a proxy of health in #seabirds
@Ecophy_CEBC @MarineMegafaun1 🇦🇶❄️🐧🔬🧬
Starting October 1
#PhDposition
DM if interested

Supplementing #cell culture medium with #deoxythymidine drives #telomere elongation, according to a recent article of William Mannherz and Suneet Agarwal (Dana-Farber / Harvard), published in Nature Genetics. https://www.nature.com/articles/s41588-023-01339-5

'Pot1 is a subunit of telomere capping complex that binds to the G-rich overhang and inhibits the activation of DNA damage checkpoints. In this study, we explore new functions of fission yeast Pot1 by using a pot1-1 temperature sensitive mutant'
@miguelgf et al

#telomeres #telomere

https://www.biorxiv.org/content/10.1101/2023.01.23.525167v1

@xabitron1
also on a personal note,from absolutely nowhere started getting significant amounts of white hair which is a DEFINITIVE sign of #telomere aging

it seems to be mostly growing in one area on my front left side & 🤞🏼🤞🏼it comes in like a cool Cruella De Vil-ish streak🖤,but it is definitely a bizarre happening for me

Aside from 2.5 #covid infections, I work VERY hard to be stress free

If I HAD to random guess estimate I’ve aged 6~ years. Nobody escapes this #CovidIsNotOver

@ZeroCovidColin
People don’t seem to care about what matters to me the most… health, mental capacity & caring about other people who too live on this earth… so now I’m going in the complete opposite direction

Aging aging aging aging aging aging like Dorian Gray’s portrait dammit!

Our society is all about #facade #appearances #vanity #youth

#telomere shortening from #reinfection of #Covid #EndothelialDamage

I think #aging freaks people out🤷🏻‍♀️more than internal organ damage🙄🤦🏻‍♀️or brain function

https://nitter.pussthecat.org/tactnowinfo/status/1618488013348294656?s=46
@TACTNowinfo 22 links to #CovidPapers #telomere #ImmuneDysfunction
Haven’t seen the sun since 1989, especially w/out sunblock but I’m relatively ambivalent about #aging

Def more concerned about internal aging,which as a perk, affects the outside
It could be my imagination,but as a fine art artist, we naturally look at minutiae of details #wrinkles & I swear people are #prematureAging like Bowie The Hunger
White/grey hair is a visible sign of #telomereShortening #FYI

Happy to report our review in Current Atherosclerosis Reports!

#Telomere Length: Implications for Atherogenesis

by me & my supervisor Dr. J. Geoffrey Pickering

TL as a biomarker & causal factor for ASCVD
Evidence from seminal studies, incld #UKBiobank #TOPMed
https://link.springer.com/article/10.1007/s11883-023-01082-6

Re: my question of an extra or extra pair of #telomere #telomeres and #cancer and this recording: it’s sent with the #intention of #forthehighestgood and to help, and I do not believe that causes cancer. And, #systemsofbelief in this, which are individual and collective as I understand #tribal #tribalism as is the human experience of being connected to other humans (#LeeHarris #LeeHarrisEnergy #channeling #TheZs ‘the human suits are magnetic’)

And, use your best judgement.

And, you also

https://youtu.be/VYmpxspjrGs #Telomere #Telomeres #energyexercises #energy #energyrecording

Would you live longer with an extra #telomere #telomeres or is that #cancer? Could be either? ❤️🙏🏻🕊✌🏻🇺🇦🇷🇺🙏🏻

https://en.wikipedia.org/wiki/Telomere Okay, yes, perhaps #Telomere #Telomeres ❤️🕊✌🏻🙏🏻🇺🇦🇷🇺❤️

@PrecautionaryPrinciple
I mean…uuuuhhhhhhh…hmmmm
I’m sure being in nature is great for one’s mental health & have a friend of mine that is constantly recommending I go take a walk..but tbh just not keen on the great outdoors

It’s like a bath. Some people love it & can stay in there for inordinate amounts of time. I cannot; I get instantaneous bored

The ideas they are “Rx”ing make me stressed just reading them

Been getting through a #telomere book & see where they are going, but Rx?….NO #nope

The latest episode of the EMBO Podcast #EMBOPodcast is out 🎧

I spoke with Roger Reddel & Tracy Bryan at Sydney's Children's Medical Research Institute about their classic 1995 @embojournal paper describing #telomerase independent #telomere lengthening in immortalised cell lines. It challenged conventional wisdom at the time - and it was Bryan's PhD project, quite a way to get started in science.

@miguelgf provided some perspective on the work and its enduring significance and editor @HVodermaier explained #EMBOJournal's interest in studies with striking findings that may not provide a full mechanistic description.

You can listen to "ALTernative immortality" at the link below or on your preferred podcast app. Special thanks to Igor Jukic & audio producer extraordinaire @marcoantonio

https://www.embo.org/podcasts/alternative-immortality/

New cross-journal article collection on #aging & #senescence - why not add a new browser tab to your holiday reading list?

👉 https://www.embopress.org/page/collections/aging-senescence-2022

#genome stability
#chromatin
#metabolic plasticity
#tau aggregation
#telomere dysfunction #immunoaging

@embojournal @emboreports @EmboMolMed @MolSystBiol Illustration © SciStories LLC

Liz Parrish describes the long-term effects of her life-extension gene therapy in 2015. FULL INTERVIEW: https://youtube.com/watch?v=uHX-cw2afTc

#Genetics #genetherapy #Futurism #biotech #tech
@ParrishLiz
#telomere #MedicalResearch #bioviva #longevity #Transhumanism
@ageing