New research article in The Lancet HIV>

Efficacy, safety, and tolerability of switching to long-acting #cabotegravir plus #rilpivirine versus continuing fixed-dose #bictegravir, #emtricitabine, and #tenofovir alafenamide in virologically suppressed adults with #HIV, 12-month results (SOLAR): a randomised, open-label, phase 3b, non-inferiority trial

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(23)00136-4/fulltext

New research article in The Lancet HIV>

Pregnancy and neonatal safety outcomes of timing of initiation of daily oral #tenofovir disoproxil fumarate and #emtricitabine pre-exposure prophylaxis for #HIV prevention (CAP016): an open-label, randomised, non-inferiority trial

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00369-1/fulltext

#PrEP

Thuốc Viread 245mg điều trị viêm gan B mua ở đâu?

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Specific suppression of long terminal repeat retrotransposon mobilization in plants
#Retrotransposons #TransgenicPlants #GenomeInestability #Tenofovir
https://academic.oup.com/plphys/advance-article/doi/10.1093/plphys/kiac605/6965411

RT @_MiguelHernan
1/ Men with #HIV on TDF (#tenofovir disopropoxil fumarate) had

half the risk of #COVID19 hospitalization and ICU admission

than those on other antiretrovirals.

We adjusted for all known confounders. Alternative explanations anyone?

Work led by @gli942
https://pubmed.ncbi.nlm.nih.gov/35848570/

Of >50,000 persons with #HIV in Spain, those on TDF (#tenofovir disopropoxil fumarate) had

44% lower #COVID19 hospitalization risk

70% lower ICU admission risk

than those on TAF.

Work led by Julia del Amo.

https://journals.lww.com/aidsonline/Fulltext/2022/12010/Tenofovir_disoproxil_fumarate_emtricitabine_and.11.aspx

Evidence keeps mounting but no randomized trials yet.

Men with #HIV in the United States who were on TDF (#tenofovir disopropoxil fumarate) had

half the risk of #COVID19 hospitalization and ICU admission

than those on other antiretrovirals.

Work led by Katherine Li

https://pubmed.ncbi.nlm.nih.gov/35848570/

We adjusted for all known confounders. Alternative explanations anyone?

TDF (#tenofovir disopropoxil fumarate) is a cheap, safe antiretroviral to treat and prevent #HIV.

#Observational studies have found that TDF users have a much lower risk of severe #COVID19 than users of other antiretrovirals (including TAF, another tenofovir prodrug).

How come no randomized trials of TDF exist? If interested in the repurposing of known antivirals to prevent serious #COVID19, watch my talk here

https://play.ki.se/media/Miguel+Hern%C3%A1n+-+22+03+2022/0_ge5wg9fm/373731

Links to the 2 most recent studies (just published) below.